PLT、NT-pro BNP、D-二聚体对川崎病合并冠脉病变的预测价值
Predictive value of PLT,NT pro BNP,D-dimer for Kawasaki disease complicated with coronary artery lesions
程瑞朵 1理真真 1李英1
作者信息
- 1. 河南大学淮河医院儿科,河南开封 475000
- 折叠
摘要
目的:探讨PLT、NT-pro BNP及D-二聚体对川崎病(KD)合并冠状动脉病变(CAL)的预测价值.方法:将纳入研究的110例患儿分为冠状动脉病变组(CAL组)和非冠状动脉病变组(NCAL组),分析其实验结果,探讨KD合并CAL的独立危险因素,并绘制构建受试者工作特征曲线(ROC),计算PLT、NT-pro BNP、D-二聚体的预测效能.结果:PLT(OR=1.018,95％CI=1.003～1.033,P=0.016)、NT-pro BNP(OR=1.016,95％CI=1.006～1.026,P=0.002)及 D-二聚体(OR=2.280,95％CI=1.268～4.100,P=0.006)为 KD 合并 CAL 的独立危险因素(P＜0.05).PLT、NT-pro BNP、D-二聚体三者联合预测CAL的ROC曲线下面积为0.866,敏感度为80.5％,特异度为79.7％.结论:PLT、NT-pro BNP和D-二聚体是KD合并CAL的独立危险因素,且三者联合较单独使用预测价值更高.
Abstract
Objective:To investigate the predictive value of PLT,NT pro BNP and D-dimer for Kawasaki disease(KD)complicated with coronary artery lesions(CAL).Methods:110 children included in the study were divided into coronary artery lesions group(CAL group)and non coronary artery lesions disease group(NCAL group).Analyze the experimental results and explore the independent risk factors of KD complicated with CAL,and the receiver operating characteristic curve(ROC)was constructed to calculate the predictive power of PLT,NT pro BNP,D-dimer.Results:PLT(OR=1.018,95％CI=1.003～1.033,P=0.016),NT pro BNP(OR=1.016,95％CI=1.006～1.026,P=0.002)and D-dimer(OR=2.280,95％CI=1.268～4.100,P=0.006)were independent risk factors for KD with CAL(P＜0.05).The area under the ROC curve of the combination of PLT,NT-pro BNP and D-dimer for predicting CAL was 0.866,the sensitivity of 80.5％and specificity of 79.7％.Conclusion:PLT,NT-pro BNP,and D-dimer were independent risk factors for KD with CAL,and their combination had a higher predictive value than when used alone.
关键词
川崎病/冠状动脉病变/血小板/N端脑钠肽前体/D-二聚体Key words
Kawasaki disease/coronary artery lesion/platelet/N-terminal brain natriuretic peptide precursor/D-dimer引用本文复制引用
基金项目
河南省科技攻关计划(222102310175)
出版年
2024
NETL
NSTL
万方数据