Research progress of ABCB5 gene,LEF1 gene and hypertension
Many factors and molecular pathways are involved in the pathogenesis of arterial hypertension.The ATP-binding cassette superfamily member ABCB5 has recently been linked to cardiovasmo-related diseases and the WNT signaling pathway,with reports suggesting a role for the Wnt/β-catenin pathway in the course and progression of hypertension.As a key transcription factor in WNT signaling pathway,LEF1 may cause hypertension,through related mechanisms.This article reviews the correlation between LEF1 and WNT signaling pathway.