Many factors and molecular pathways are involved in the pathogenesis of arterial hypertension.The ATP-binding cassette superfamily member ABCB5 has recently been linked to cardiovasmo-related diseases and the WNT signaling pathway,with reports suggesting a role for the Wnt/β-catenin pathway in the course and progression of hypertension.As a key transcription factor in WNT signaling pathway,LEF1 may cause hypertension,through related mechanisms.This article reviews the correlation between LEF1 and WNT signaling pathway.
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