SERPINE1's expression and prognosis in Colon Cancer and its mechanism of action
Objective:To explore the relationship between the differential expression of serine protease inhibitor 1(SERPINE1)and prognosis in colon cancer and its molecular biological mechanism.Methods:After obtaining sample RNAseq data and clinical information from TCGA and GTEx databases,SERPINE1 expression and prognostic survival analysis,univariate and multivariate Cox regression analysis and its correlation with pathway genes were performed according to the grouping.Results:① SERPINE1 was highly expressed in patients with colon cancer.② There was no significant difference in age,sex,race and recurrence type,but there was significant difference in lymph node metastasis,distant metastasis and pTNM stage(P＜0.01),and had significant effect on prognosis and survival(P＜0.01).③ The prognostic analysis of high and low expression groups showed that the non-progressive survival time was short and the risk coefficient was high in the high expression group,and vice versa.④ Univariate and multivariate Cox regression analysis showed that SERPINE1 was an independent risk factor for prognostic survival.⑤ The Spearman correlation analysis between SERPINE1 gene and pathway score showed that it was strongly correlated with the molecular mechanism of epithelial mesenchymal cell transformation(EMT),angiogenesis and extracellular matrix(ECM)degradation(P＜0.01,r＞0.6).Conclusion:The expression of SERPINE1 is increased in colon cancer,especially in patients with lymphatic metastasis,distant metastasis and advanced stage,which suggests that the prognosis of patients is poor,which is an independent risk factor for prognosis.In addition,SERPINE1 may be involved in EMT,tumor angiogenesis and ECM degradation in the occurrence and development of colon cancer.SERPINE1 may be a potential new molecule in the diagnosis,treatment and prognosis of colon cancer.
万方数据
维普
