The causal relationship between osteoporosis and hyperparathyroidism:a bidirectional two sample Mendelian randomization study
Objective:To explore the causal relationship between osteoporosis and primary hyperparathyroidism,we used a bidirectional,two-sample Mendelian randomization approach and assesses the presence of reverse causality between the two conditions.Methods:Single nucleotide polymorphisms(SNPs)related to osteoporosis were obtained from the UK Biobank,and SNPs related to primary hyperparathyroidism were obtained from the FinnGen database.The main analysis was conducted using the Inverse-Variance Weighted(IVW)method,and additional regression models,including MR-Egger,Weighted Median(WME),simple mode,and weighted mode,were used to evaluate causal effects.Sensitivity,heterogeneity,and pleiotropy tests were performed to assess the stability and reliability of the results.Results:Using the IVW method as the main analysis model for the selected GW AS data for primary hyperparathyroidism and osteoporosis,the IVW result for osteoporosis on primary hyperparathyroidism was OR=0.960,95％CI=0.433 to 2.13,P=0.551,indicating no significant causal effect(P＞0.05).The IVW result for primary hyperparathyroidism on osteoporosis was OR=0.998,95％CI=0.996 to 1.000,P=0.036,indicating a statistically significant causal effect(P＜0.05).Various sensitivity analyses showed no sensitivity,pleiotropy,or heterogeneity in the study,indicating the results has good robustness.Conclusion:Using a bidirectional,two-sample Mendelian randomization approach,we could not establish a causal relationship between osteoporosis and primary hyperparathyroidism from a genetic variation perspective.However,we confirmed a causal relationship between primary hyperparathyroidism and osteoporosis from a genetic variation perspective,aligning with clinical pathological and physiological mechanisms.There was no evidence of reverse causality between the two conditions.This study contributed to the clinical diagnosis and treatment of osteoporosis and primary hyperparathyroidism and provided a reference for the study of the underlying mechanisms between these two conditions.
osteoporosisprimary hyperparathyroidismmendelian randomizationparathyroid hormone1,25-dihydroxyvitamin D
万方数据
维普
