Distribution and drug resistance of pathogenic bacteria in blood culture in Xinxiang area from 2019 to 2023
Objective:To analyze the distribution and drug resistance of pathogenic bacteria in blood culture in Xinxiang area,and to provide reference for rational application of antibiotics in clinical bloodstream infection.Methods:The clinical distribution and drug resistance of pathogens from blood culture positive strains from January 2019 to September 2023 of the First Affiliated Hospital and the Second Affiliated Hospital of Xinxiang Medical University were retrospectively analyzed.Results:A total of 3 816 strains blood positive culture isolates were collected from patients with bloodstream infection,including 2 079 strains of Gram-negative bacteria(54.48％),1536 strains of Gram-positive bacteria(40.25％)and 201 strains of fungi(5.27％).The top six pathogens were 905 strains of Escherichia coli(23.72％),475 strains of Klebsiella pneumoniae(12.45％),325 strains of Staphylococcus epidermidis(8.52％),283 strains of Staphylococcus hominis(7.42％),179 strains of Staphylococcus aureus(4.69％),and 91 strains of Acinetobacter baumannii(2.38％),the top three isolates of fungi were 70 strains of Candida albicans(1.83％),35 strains of Candida tropicalis(0.92％)and 29 strains of Candida Dubliniensis(0.76％).The drug susceptibility results showed that Escherichia coli had high sensitivity to carbapenems and amikacin,which resistance was less than 5％,and the resistance of Klebsiella pneumoniae to imipenem and meropenem was 34.7％and 33.5％,respectively.The detection rate of methicillin-resistant in Staphylococcus aureus(MRSA)and Staphylococcus epidermidis(MRSE)were 31.8％and 53.4％.The vancomycin-resistant staphylococcus and Enterococcus were not found.Conclusion:Gram-negative bacteria were the main pathogens of blood culture in Xinxiang area,Escherichia coli was the main isolated bacteria,and the resistance rate of Klebsiella pneumoniae to carbapenems was high.It is necessary to monitoring and analysis the distribution and resistance characteristics of pathogenic bacteria isolated from blood culture can provide a scientific basis for clinicians to rationally select antibiotics,so as to reduce the generation of drug-resistant strains and effectively control bloodstream infection.
万方数据
维普
