Research advancement in animal models of oral cancer
The key words of animal model,oral cancer,oral cancer animal model and oral cancer research were searched to summarize the clinical characteristics of oral cancer,and to analyze the establishment methods,advantages and disadvantages of animal models used in the mechanism research and clinical treatment research of oral cancer.Results demonstrated that animal models that were closer to the pathogenesis of human oral cancer can be created through gene editing technology.Immunodeficient animals were important for the study of immunotherapy for oral cancer and the interaction between tumors and the host immune system.The chemical induction model could well simulate the occurrence process of human oral cancer.The modeling period of xenograft model was short,and the data of tumor growth could be obtained in a short time,which is conducive to high-throughput screening and drug evaluation.However,all the above modeling methods have certain limitations.In order to simulate the complexity of human oral cancer,researchers have tried to use a variety of modeling strategies together.The combined modeling strategy can create more realistic and comprehensive animal models of oral cancer.
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