Characteristics of Lipid Metabolism in Middle-aged and Elderly Male Patients with Benign or Malignant Colorectal Polyps
Objective To study the characteristics of lipid metabolism in middle-aged and elderly male patients with benign or malignant colorectal polyps.Methods Clinical data of 258 middle-aged and elderly male patients who under-went colonoscopy in the authors'hospital from January 2020 to October 2022 were retrospectively collected and divided in-to benign polyp group(n=171)and colorectal cancer(CRC)group(n=87)according to the benign and malignant status of colorectal polyps.Benign colorectal polyps were divided into non-adenomatous polyp group(n=89)and adenomatous polyp group(n=82)according to the type of pathological diagnosis.Colorectal polyps were divided into right hemicolon group(n=76)and left hemicolon+rectum group(n=182)according to the site of occurrence of colorectal polyps.Ac-cording to the number of colorectal polyps,they were divided into single polyp group(n=155)and multiple polyp group(n=103).The independent risk factors and the differences of different pathological types,polyp sites and number of pol-yps of benign and malignant colorectal polyps in middle-aged and elderly male were analyzed.Results Logistic regression analysis showed that age(OR=1.064,95％CI:1.030-1.098,P＜0.001),fasting plasma glucose(FPG)(OR=1.182,95％CI:1.042-1.340,P=0.009)and triglyceride(TG)(OR=1.261,95％CI:1.028-1.547,P=0.026)were inde-pendent risk factors for CRC.The age of patients in adenomatous polyp group was higher than that of patients in non-ade-nomatous polyp group,and the difference was statistically significant(P＜0.05).FPG of patients in right hemicolon group was higher than that of patients in left hemicolon+rectum group,and the difference was statistically significant(P＜0.05).Comparison of the indicators between patients in single polyp group and multiple polyp group showed no sta-tistically significant difference(P＞0.05).Conclusion The results suggest that changes in lipid metabolism levels are po-tential risk factors for malignant colorectal lesions in middle-aged and elderly male patients.Among middle-aged and eld-erly male patients,the degree of colorectal polyp malignancy is correlated with age,FPG and TG levels.Middle-aged and elderly male patients with advanced age,high levels of FPG and high levels of TG are more likely to develop CRC.Advanced age is associated with the de-velopment of adenomatous colorectal polyps.Elevated FPG levels are associated with the development of right hemicolonic polyps.
Middle-aged and elderly populationColorectal PolypsColorectal cancerLipid metabolism
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