铜死亡相关基因DLAT在胰腺癌中的表达及临床意义
Expression and Clinical Significance of Cuproptososis-related Gene DLAT in Pancreatic Cancer
张钦泉 1匡鹏 2董毅 2王理承 2毛连春 1李中虎 2金炜东2
作者信息
- 1. 430065 湖北武汉,武汉科技大学医学部医学院
- 2. 中部战区总医院普通外科
- 折叠
摘要
目的 探讨铜死亡相关基因在胰腺癌中发挥的作用,构建预后模型,筛选并验证铜死亡相关基因在胰腺癌中发挥的重要作用.方法 利用生物学数据库分析胰腺癌中铜死亡相关基因的表达水平、预后分析并构建预后模型.结果 以二氢硫辛酰胺S-乙酰转移酶(dihydrolipoamide S-acetyltransferase,DLAT)为代表的铜死亡相关基因在胰腺癌中高表达(P均＜0.05).以铜死亡相关基因构建预后模型,与低风险评分胰腺癌患者相比,高风险评分胰腺癌患者预后较差(P＜0.05).公共数据库及临床数据的免疫组织化学法验证了 DLAT在胰腺癌中高表达不利于胰腺癌患者预后,其表达水平可作为胰腺癌患者病情进展的独立危险因素(P均＜0.05).结论 铜死亡相关基因可以作为胰腺癌患者潜在的预后预测因子.以DLAT为代表的铜死亡相关基因可能为胰腺癌治疗提供新的途径.
Abstract
Objective To investigate the role of cuproptososis-related genes in pancreatic cancer,construct a prog-nostic model,screen and verify the important role of cuproptososis-related genes in pancreatic cancer.Methods The ex-pression levels of cuproptososis-related genes in pancreatic cancer were analyzed by biological database,and the prognostic analysis was performed to construct a prognostic model.Results Cuproptososis-related genes represented by dihydroli-poamide S-acetyltransferase(DLAT)were highly expressed in pancreatic cancer(all P＜0.05).Based on the prognostic model of cuproptososis-related genes,the prognosis of pancreatic cancer patients with high risk score was worse than those of patients with low risk score(P＜0.05).The immunohistochemistry method of public database and clinical data verified that the high expression of DLAT in pancreatic cancer was not conducive to the prognosis of patients with pancre-atic cancer,and its expression level could be used as an independent risk factor for the progression of pancreatic cancer pa-tients(all P＜0.05).Conclusion Cuproptososis-related genes can be used as potential prognostic factors for patients with pancreatic cancer.The cuproptososis-related genes represented by DLAT may provide a new way for the treatment of pancreatic cancer.
关键词
铜死亡相关基因/二氢硫辛酰胺S-乙酰转移酶/胰腺癌/免疫组织化学/预后Key words
Cuproptososis-related genes/Dihydrolipoamide S-acetyltransferase/Pancreatic cancer/Immunohisto-chemistry/Prognosis引用本文复制引用
基金项目
国家自然科学基金项目(81902501)
湖北省自然科学基金项目(2021CFB500)
出版年
2024
NETL
NSTL
万方数据