Analysis of the Effect of Thawing and Culturing Cleavage Embryos Blastocysts Transfers in Patients with Repeated Implanta-tion Failure
Objective To explore the use of remaining cleavage embryo thawing and culturing blastocyst transfer as a potential therapeutic strategy in patients with repeated implantation failure(RIF)and to analyze their pregnancy out-comes.Methods A total of 295 patients with RIF undergoing thawed embryo transfer were included in this study,and they were divided into cleavage embryo thawed and cultured blastocyst transfer group(n=141)and conventional thawed blastocyst transfer group(n=154)according to the source of blastocyst.The clinical pregnancy rate,implantation rate and live birth rate were compared between the two groups.Results The clinical pregnancy rate and the implantation rate of cleavage embryo thawed and cultured blastocyst transfer group were significantly higher than those of conventional thawed blastocyst transfer group(P＜0.05),and there were no significant differences in miscarriage rate,multiple birth rate and live birth rate between the two groups(P＞0.05).For patients with RIF≤4 times and RIF=5 times,the im-plantation rate in cleavage embryo thawed and cultured blastocyst transfer group was higher than conventional thawed blastocyst transfer group(P＜0.05),however,there were no significant differences in clinical pregnancy rate,miscar-riage rate,multiple birth rate and live birth rate among RIF≤4 times,RIF=5 times and RIF≥6 times patients(all P＞0.05).Conclusion When there are zero blastocyst in RIF patients,thawing the remaining cleavage embryos and culturing the blastocysts for transfer can improve clinical pregnancy rate and implantation rate,which is an effective treatment strategy.
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