Clinical Efficacy of Jinlida Granules in Adjuvant Treatment of Diabetic Peripheral Neuropathy with Cognitive Dysfunction
Objective To investigate the clinical efficacy of the Chinese patent medicine Jinlida granules in the adju-vant treatment of diabetic peripheral neuropathy(DPN)patients with cognitive dysfunction.Methods A total of 80 DPN patients with cognitive dysfunction who presented at the department of endocrinology of the authors'hospital from 1,December 2022 to 31,March 2023 were selected.The subjects were divided into observation group and control group by randomized envelope method,with 40 patients in each.The two groups of patients were given premixed insulin for hypo-glycemic treatment,and at the same time they were given epinastat tablets for nutritional nerve treatment,and the obser-vation group was added Jinlida granules on this basis,with 12 weeks of treatments for both two groups of patients.Before and after the treatment,the patients'cognitive functions were assessed by Mini-Mental State Examination(MMSE),Chi-nese version of Montreal Cognitive Assessment(MoCA),and Michigan Neuropathy Screening Instrument(MNSI)as well as lower limb electromyography were used to assess the severity of peripheral neuropathy,and the levels of blood glucose,blood lipid and haemoglobin A,c(H IbA1c)were measured.Results After 12 weeks of the treatments,the visual space,executive capacity and total score of MoCA,the total effective rate of DPN treatments in the observation group were significantly higher than those in the control group(P＜0.05);but the difference between the MMSE score and MNSI score was not statistically significant(all P＞0.05);the postprandial 2-hour blood glucose(2hPG),HbA1 c,total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)were significantly lower than those in the control group,and high density lipoprotein cholesterol(HDL-C)was significantly higher than that in the control group,the difference between the two groups was statistically significant(P＜0.05).Conclusion The efficacy of Jinlida granules in the adjuvant treatment of DPN with cognitive dysfunction is excellent.
NETL
NSTL
万方数据
