Effects of Extracorporeal Shock Wave Therapy on Wound Healing of Diabetic Foot Ulcer in Rabbits
Objective To investigate the effects of extracorporeal shock wave therapy(ESWT)on wound healing of diabetic foot ulcers(DFU)in rabbits.Methods A total of 40 New Zealand white rabbits weighing 2-3 kg were select-ed,the rabbits DFU animal model was established by high-fat feeding and intravenous infusion of alloxan solution,the rabbits were divided into DFU group(treated with simulated shock wave therapy,n=10),ESWT1 group(treated with ESWT above the wound level,n=10),ESWT2 group(treated with ESWT around the wound,n=10)and ESWT3 group(treated with ESWT above the wound level combined with ESWT around the wound,n=10)according to the ran-dom number table method.After 4 weeks of interventions,the ulcer area of rabbits in each group was measured before and after intervention,and the wound healing rate was calculated.Results Compared with the rabbits in DFU group,the wound healing rates of the rabbits in ESWT1 group,ESWT2 group and ESWT3 group significantly increased(all P＜0.05),the wound healing rate of rabbits in ESWT3 group was significantly higher than that in ESWT1 group and ESWT2 group(all P＜0.05).Conclusion ESWT can promote the healing of DFU,and the treatment effects of the prox-imal combined with the surrounding area of the wound is better than that of a single plane.
Extracorporeal shock wave therapyDiabetic foot ulcerComplication of diabetes mellitus
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