目的 研究高血压脑出血患者采用丁苯酞氯化钠注射液联合尼莫地平片治疗的临床疗效,以及对脑水肿与血流参数的影响.方法 对2020-01/2021-01月作者医院收治的98例高血压脑出血患者的临床资料进行回顾性分析.按照治疗方式不同进行分组,其中对照组(n=48)在常规治疗的基础上口服尼莫地平40 mg/次,3次/天,连续给药14天;研究组(n=50)在对照组治疗基础上联用丁苯酞氯化钠注射液静脉滴注治疗,100 ml/次,2次/天,连续给药14天.对两组总有效率、治疗前后美国国立卫生研究院卒中量表评分(National Institute of Health Stroke Scale,NIHSS)、脑水肿体积、血肿体积、平均血流速度、平均血流量进行比较.结果 研究组总有效率高于对照组(94.00％vs.79.17％,P＜0.05);治疗前,两组NIHSS评分、脑水肿体积、血肿体积、平均血流速度、平均血流量均差异无统计学意义(P均＜0.05);治疗后,研究组NIHSS评分、脑水肿体积、血肿体积均显著小于对照组,平均血流速度、平均血流量均显著大于对照组(P均＜0.05).结论 高血压脑出血患者给予丁苯酞和尼莫地平联合治疗,可以更有效地改善患者临床疗效、脑水肿和血流动力学,恢复患者缺损的神经功能.
Clinical Effects of Butylphthalide Combined with Nimodipine on Hypertensive Cerebral Hemorrhage and Its Influence on Cer-ebral Edema and Blood Flow Parameters
Objective To study the clinical effects of butylphthalide combined with nimodipine on hypertensive cer-ebral hemorrhage and its influence on cerebral edema and blood flow parameters.Methods The clinical data of 98 patients with hypertensive cerebral hemorrhage in author's hospital from January 2020 to January 2021 were retrospectively ana-lyzed.The patients were divided into control group(n=48)and study group(n=50)according to the different treatment methods.The control group was given nimodipine 40 mg/times,3 times/day for 14 days on the basis of conventional treatment;on the basis of the treatment of the control group,the study group used butylphthalide treatment,100 ml/times,2 times/day,continuous administration for 14 days.The total effective rate of the two groups after treatments and National Institute of Health Stroke Scale(NIHSS),cerebral edema volume,hematoma volume,average blood flow veloc-ity,average blood flow of patients before and after treatments between the two groups were compared.Results The total effective rate of study group was higher than control group(94.00％vs.79.17％,P＜0.05);before treatments,there was no significant difference in NIHSS score,brain edema volume,hematoma volume,average blood flow velocity and average blood flow between the two groups(all P＜0.05);after treatments,the NIHSS score,brain edema volume and hematoma volume of the study group were significantly smaller than those of the control group,and the average blood flow velocity and average blood flow were significantly higher than those of the control group(all P＜0.05).Conclusion The combined administration of butylphthalide and nimodipine for patients with hypertensive cerebral hemor-rhage can effectively improve the clinical efficacy,cerebral edema and hemodynamics,and more effectively recover the de-fective nerve function of the patients.
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