Clinical Value and Significance of Cardial Myosin Binding Protein-C in the Diagnosis of Early Onset Acute Myocardial Infrac-tion
Objective To analyze the expression level of serum cardiac myosin binding protein C(cMyBP-C)in ear-ly onset acute myocardial infarction(AMI)patients,and to explore its clinical value and significance in diagnosis and dif-ferential diagnosis of early onset AMI.Methods A total of 99 early onset AMI patients who were admitted to department of cardiovascular medicine of author's hospital from October 2021 to October 2022 were selected,including 51 non ST-segment elevation myocardial infarction(NSTEMI)patients(NSTEMI group)and 48 ST-segment elevation myocardial infarction(STEMI)patients(STEMI group);and 48 hospitalized patients without coronary atherosclerotic heart disease were selected as the control group.The levels of cMyBP-C were compared among the three groups at admission,3h and 12h after admission respectively,and compared with the serum cardiac troponin T(cTnT)measured at the same time.The efficacy of cMyBP-C in the diagnosis of AMI and the differential diagnosis of STEMI and NSTEMI at different timing were analyzed by receiver operating characteristic(ROC)curve.Results cMyBP-C increased at admission in patients with early onset AMI and significantly increased 3h after admission,and significantly decreased at 12h after admission;com-pared with cTnT,cMyBP-C increased earlier,peaked earlier and subsided more rapidly.ROC curve analysis showed that during the diagnosis of NSTEMI,the ROC area under curve(AUC)of cMyBP-C at each timing was better than that of cTnT.In the diagnosis of STEMI,the diagnostic efficacy of cMyBP-C measured at admission and 3h after admission was superior to that of cTnT,the diagnostic efficacy of cMyBP-C measured at 12h after admission was inferior to that of cTnT.In the differential diagnosis of STEMI and NSTEMI,cMyBP-C was superior to cTnT measured at admission and 3h after admission;however,the diagnos-tic effective of cMyBP-C was less than cTnT at 12h after admission.Conclusion The level of cMyBP-C in patients with early onset AMI increases immediately upon admission,significantly increases at 3h after admission,and significantly de-creases at 12h after admission;compared with cTnT,cMyBP-C can not only be used as a biomarker with higher sensitivi-ty in diagnosis of early onset AMI,but also facilitate the differential diagnosis of STEMI and NSTEMI.
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