Impact of Abnormal Sperm Morphology on the Clinical Pregnancy of Intrauterine Insemi-nation
Objective To investigate the impact of sperm morphology on the clinical pregnancy of intrauterine in-semi-nation(IUI).Methods The clinical data of 310 infertile couples who underwent IUI for the first time at author's hospital reproductive center from January 2019 to December 2023 were retrospectively analyzed.The patients were divid-ed into pregnancy group(63 couples)and non-pregnancy group(247 couples)based on pregnancy outcomes.Assessed the impact of the percentage of normal sperm morphology and sperm deformity rate on the clinical pregnancy.Results There were no statistically significant differences in age,days of sexual abstinence and duration of infertility between the two groups(P＞0.05).There were no statistically significant differences in the percentage of normal sperm morphology rate(≥4.0％and＜4.0％),excess residual cytoplasm,sperm midpiece abnormality rate,sperm fragmentation rate and sperm viability rate between the two groups of male patients(P＞0.05).The sperm head morphology abnormalities rates in pregnant group was significantly lower than that in non-pregnancy group,while the sperm tail morphology abnormali-ties rate was significantly higher than that in non-pregnancy group(all P＜0.05).Conclusion Sperm morphology has a significant influence on clinical pregnancy of IUI,in particular,semen samples with low head malformation rate are more likely to get pregnant,while sperm with tail malformation may be successfully fertilized through compensation mechanism or screening technology despite abnormal morphology.Clinically,semen analysis and other fertility parameters should be combined to improve the clinical pregnancy rate of artificial insemination.
Sperm morphologyIntrauterine inseminationSperm head deformityClinical pregnancy
NETL
NSTL
万方数据
