Effects of Probucol on Serum Inflammatory Factors,Oxidative Stress,Lipid Metabolism,Renal Function and Podocyte Func-tion in Patients with Nephrotic Syndrome
Objective To observe the effects of Probucol on serum inflammatory factors,oxidative stress,lipid me-tabolism,renal function and podocyte function in patients with nephrotic syndrome(NS).Methods A total of 76 pa-tients with NS were randomly divided into control group and observation group according to numerical table method,with 38 patients in each,the patients in the control group were orally treated with Prednisone acetate tablet combined with Cy-clophosphamide after admission,and the patients in observation group were orally treated with Probucol 0.5 g/time,twice/d on the basis of the control group.Both groups were treated continuously for 12 weeks.Serum inflammatory fac-tor serum interleukin 6(IL-6),tumor necrosis factor alpha(TNF-α),hypersensitive C-reactive protein(hs-CRP),oxida-tive stress indexes superoxide dismutase(SOD),malondialdehyde(MDA),8-hydroxy deoxyguanosine(8-OHdG),lipid metabolism triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),total cholesterol(TC),renal function indexes serum creatinine(Scr),blood urea nitrogen(BUN),24 h urinary pro-tein quantification,podocyte function indexes podocalyxin(PCX)and podocin nephrin of patients in both groups before and after treatment were measured.Results There were no significant differences in serum inflammatory factors,oxida-tive stress,lipid metabolism,renal function and podocyte function between the two groups before treatment(all P＞0.05).The level of SOD in the observation group was higher than that in the control group after treatment(P＜0.05),but the levels of MDA,8-OHdG,TG,HDL-C,LDL-C,TC,serum inflammatory factors,renal function and podocyte function were significantly lower than those in the control group(all P＜0.05),no serious adverse reactions occurred during treatments in both groups.Conclusion The adjuvant therapy of Probucol for the patients with NS can significantly reduce the inflammatory and oxidative stress reac-tion,improve lipid metabolism,renal function and podocyte function.
ProbucolNephrotic syndromeInflammatory factorOxidative stressPodocyte function
NETL
NSTL
万方数据
