目的 分析某地区军队人员常见慢性病发生的拐点年龄,指导该地区军队人员高血压、高血糖、血脂异常的风险分层管理,精准施策,进而为全军慢性病早期诊断和控制提供理论依据.方法 收集某医院近5年在健康医学科进行健康体检的军队人员为研究对象,提取其一般信息(性别、年龄),血压、血糖及血脂指标等临床资料.绘制年龄预测高血压、空腹高血糖及血脂异常发生的受试者工作特征(receiver operating characteristic,ROC)曲线,并确定其发生率变动的拐点年龄,验证拐点年龄前后高血压、空腹高血糖及血脂异常发生率的变化情况.结果 某地区军队体检人群性别比例男∶女为5.57∶1,年龄分布16～103岁,20～55岁是体检的主要人群,占比达87.89％.高血压、空腹高血糖及血脂异常的发生率分别为5.68％,6.32％,17.85％.男性和女性高血压发生的拐点年龄分别为43.5岁,48.5岁,曲线下面积(area under the curve,AUC)分别为0.766,0.864;男性和女性空腹高血糖发生的拐点年龄分别为43.5岁,44.5岁,AUC分别为0.843,0.835;男性和女性血脂异常发生的拐点年龄分别为30.5岁,43.5岁,AUC分别为0.706,0.753.＞43.5岁男性人群高血压的发生风险是≤43.5岁的5.682倍(x2=2781.131,P＜0.001),＞48.5岁女性人群高血压的发生风险是≤48.5岁的20.604倍(x2=1270.874,P＜0.001);＞43.5岁男性人群空腹高血糖的发生风险是≤43.5岁的10.930倍(x2=5649.400,P＜0.001),＞44.5岁女性人群空腹高血糖的发生风险是≤44.5岁的8.833倍(x2=667.902,P＜0.001);＞30.5岁男性人群血脂异常的发生风险是≤30.5岁的8.706倍(x2=4761.735,P＜0.001),＞43.5岁女性人群血脂异常的发生风险是≤43.5岁的5.270倍(x2=810.441,P＜0.001).结论 高血压、空腹高血糖及血脂异常的发生均具有明显的年龄拐点,且拐点年龄前后疾病发生的风险明显不同,拐点年龄后疾病发生率呈倍数增加,提示对军队相关风险人群积极开展系列慢病科普活动,给予正确生活方式指导,早预防、早干预具有重要意义.
Study on Age Inflection Point of Abnormal Blood Pressure,Blood Glucose and Blood Lipid in Military Personnel
Objective To analyze the inflection point age of common chronic diseases in military personnel in a cer-tain region,guide the risk stratification management of hypertension,hyperglycemia and dyslipidemia in military person-nel in the region,implement precise policies,and provide a theoretical basis for the early diagnosis and control of chronic diseases in the whole army.Methods Military personnel who underwent health examinations in the health medicine de-partment of a certain hospital in the past 5 years were collected as research subjects,and the general information(gender,age),blood pressure,blood glucose and blood lipid indexes were extracted.The receiver operating characteristic(ROC)curve of age prediction of hypertension,fasting hyperglycemia and dyslipidemia was drawn,and the inflection age of the change in the incidence level was determined,and the changes in the incidence of hypertension,fasting hyperglycemia and dyslipidemia before and after the inflection age were verified.Results The gender ratio of the military physical examina-tion population in a certain region was 5.57:1,and the age distribution ranged from 16 to 103 years old,20 to 55 years old was the main population for physical examination,accounting for 87.89％.The incidence of hypertension,fasting hy-perglycemia and dyslipidemia was 5.68％,6.32％and 17.85％respectively.The inflection point ages of hypertension in males and females were 43.5 and 48.5 years old respectively,with the area under the curve(AUC)of 0.766 and 0.864 respectively;the inflection point ages of fasting hyperglycemia in males and females were 43.5 and 44.5 years old respec-tively,with the AUC of 0.843 and 0.835 respectively;the inflection point ages of dyslipidemia in males and females were 30.5 and 43.5 years old respectively,with the AUC of 0.706 and 0.753 respectively.The risk of hypertension in males aged＞43.5 was 5.682 times than those aged ≤43.5(x2=2781.131,P＜0.001),and the risk of hypertension in females aged＞48.5 was 20.604 times than those aged ≤48.5(x2=1270.874,P＜0.001).The risk of fasting hy-perglycemia in males aged＞43.5 was 10.930 times than those aged ≤43.5(x2=5649.400,P＜0.001).The risk of fasting hyperglycemia in females aged＞44.5 was 8.833 times than those aged ≤44.5(x2=667.0902,P＜0.001);the risk of dyslipidemia in males aged＞30.5 was 8.706 times than those aged ≤30.5(x2=4761.735,P＜0.001),and the risk of dyslipidemia in females aged＞43.5 was 5.270 times than those aged ≤43.5(x2=810.441,P＜0.001).Conclusion The occurrence of hypertension,fasting hyperglycemia and dyslipidemia has obvious age inflection points,and the risk of disease occurrence before and after the inflection point is significantly different.The incidence of disease increases exponentially after the inflection point,suggesting that it is of great significance to actively carry out a series of chronic disease popular science activities for military-related risk person-nel,provide correct lifestyle guidance,and prevent and intervene early.
HypertensionFasting hyperglycemiaDyslipidemiaInflection point ageMilitary personnel
NETL
NSTL
万方数据
