Mechanisms and Clinical Translation Strategies for Targeting Non-coding RNAs to Overcome Cancer Treatment Resistance
Non-coding RNAs(ncRNAs)play a critical role in cancer treatment resistance.In recent years,studies have increasingly revealed the functions and regulatory networks of specific ncRNAs,especially long non-coding RNAs(lncRNAs)and small nucleolar RNAs(snoRNAs).This review systematically summarizes key ncRNAs involved in tumor resistance mechanisms,including their regulatory roles in DNA repair,drug efflux,apoptosis,oxidative stress,and other pathways.Additionally,it explores strategies for targeting essential ncRNAs to inhibit the progression of cancer resistance,offering new approaches to overcoming treatment resistance.The review also discusses the potential of translating these ncRNA targets into clinical therapies,analyzing current technological limitations and clinical challenges,and proposing strategic recommendations for future ncRNA-targeted therapeutic research and clinical translation.
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