靶向非编码RNA在癌症治疗耐药性中的机制与临床转化策略
Mechanisms and Clinical Translation Strategies for Targeting Non-coding RNAs to Overcome Cancer Treatment Resistance
吕洋 1姬广聚 1吉蕾1
作者信息
- 1. 河南省科学院生物医学研究所,郑州 450052
- 折叠
摘要
非编码RNA(ncRNA)在癌症的治疗耐药性中扮演了关键角色.近年来,越来越多的研究揭示了特定ncRNA的功能及其调控网络,尤其是长链非编码RNA(lncRNA)和小核仁RNA(snoRNA)等.本文系统总结了在肿瘤耐药机制中具有重要作用的ncRNA,包括其在DNA修复、药物外排、细胞凋亡、氧化应激等过程中的调控机制.同时,探索了如何通过靶向关键ncRNA来抑制癌症耐药性的发展,为克服治疗耐药性提供了新的思路.此外,还讨论了将这些ncRNA靶点转化为临床治疗的可能性,分析了目前的技术瓶颈和临床挑战,为未来的ncRNA靶向治疗研究和临床转化提出策略.
Abstract
Non-coding RNAs(ncRNAs)play a critical role in cancer treatment resistance.In recent years,studies have increasingly revealed the functions and regulatory networks of specific ncRNAs,especially long non-coding RNAs(lncRNAs)and small nucleolar RNAs(snoRNAs).This review systematically summarizes key ncRNAs involved in tumor resistance mechanisms,including their regulatory roles in DNA repair,drug efflux,apoptosis,oxidative stress,and other pathways.Additionally,it explores strategies for targeting essential ncRNAs to inhibit the progression of cancer resistance,offering new approaches to overcoming treatment resistance.The review also discusses the potential of translating these ncRNA targets into clinical therapies,analyzing current technological limitations and clinical challenges,and proposing strategic recommendations for future ncRNA-targeted therapeutic research and clinical translation.
关键词
非编码RNA/癌症耐药性/长链非编码RNA/治疗靶点/临床转化Key words
non-coding RNA/cancer resistance/long non-coding RNA/therapeutic targets clinical translation引用本文复制引用
出版年
2025
NETL
NSTL
万方数据