Analysis of chemical constituents of extracts from Onchidium verruculatum
Onchidium verruculatum,a characteristic resource in the South China Sea,was extracted and isolated by using a variety of separation and purification methods,including silica gel,Sephadex LH-20,thin layer chromatography and semi-prepared HPLC.The structures of the compounds were identified by combining their biochemical characteristics,NMR data analysis and reference comparison.Twelve compounds were isolated from Onchidium verruculatum,and their structures were identified as Cyclo-(L-Pro-L-Val)(1),Cyclo-(Pro-Ile)(2),Cyclo-(L-Pro-D-Leu)(3),Tyramine(4),Cyclo-(L-Pro-L-Phe)(5),2-Piperidone(6),Cyclo-(L-Ala-L-Pro)(7),uracil ribonucleoside(8),uracil(9),thymine(10),2'-methoxyuracil nucleoside(11),thymidine(12).Compounds(1-6,11)were isolated for the first time from Onchidium verruculatum.
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