Effects of arecoline on gut microbiota composition and neurotransmitters contents in SD rats
An attempt was made to understand the effects of arecoline on gut microbiota composition and neurotransmitters contents in SD rats based on the microbiota-gut-brain axis.Three groups of SD rats were administered with arecoline hydrobromide(Ah)solution dissolved in 0.9%NaCl aqueous solution by gavage for 28 days,and the ratios of weight of Ah/rat were 500,100 and 0(control group)mg·kg-1 after administration.Then the composition of intestinal microbes in colon,the contents of short-chain fatty acids in feces and the contents of neurotransmitters in the cerebral cortex and serum were determined and analyzed.The results showed that the Ah,when administered to SD rats,increased relative abundance of Lactobacillus and Bifidobacterium,and the contents of acetic acid and propionic acid in the gut,and the contents of excitatory neurotransmitters like DA and 5-HT in the cerebral cortex,and reduced the content of GABA which is inhibitory neurotransmitters.These results indicate that arecolineAh regulates the physiological metabolism and behavior of SD rats through microbiota-gut-brain axis,leading to symptoms such as hyperactivity,loss of appetite,and weight loss in SD rats.
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