Application of GPX4 mediated Ferroptosis in chemosensitivity enhancement of glioma
Objective To observe the effect of GPX4 mediated Ferroptosis on chemosensitivity enhancement of glioma.Methods Pro-spective study included glioma patients admitted to the Neurosurgery Department of the Third People's Hospital of Henan Province from January 2020 to May 2022.According to the chemotherapy regimen,they were divided into a temozolomide chemotherapy group(control group)and a curcumin assisted temozolomide chemotherapy group(observation group).Follow up for 1 year,compare baseline data,GPX4 expression,iron death regulatory factor levels before and after treatment,as well as short-term efficacy and long-term survival between two groups of patients.A total of 100 patients were included,with 50 patients in each group.There was no statistically significant difference in baseline data between the two groups(P＜0.05).Results Before treatment,there was no statistically significant difference in GPX4 expression between the two groups of patients(P＞0.05).After 1,2,and 3 cycles of treatment,the GPX4 expression levels in the observation group were lower than those in the control group,and the difference was statistically significant(P＜0.05).Before treatment,there was no statistically significant difference in the iron death regulatory factors between the two groups of patients(P＞0.05).After treatment,the relative expression level of acyl CoA synthase long-chain family member 4(ACSL4)in the observation group was higher than that in the control group,and the relative expression level of P53 and reactive oxygen species(ROS)content were lower than those in the control group,with statistical significance(P＜0.05).The objective response rate(ORR)and disease control rate(DCR)of the observation group were higher than those of the control group,and the differences were statistically significant(P＜0.05).The survival rate,functional status score,and quality of life score(QOL)of the observation group within one year were higher than those of the control group,while the physical status score(ZPS)was lower than that of the control group,and the differences were statistically significant(P＜0.05).Conclusion Curcumin can promote GPX4 mediated ferropto-sis by inhibiting its activity,and its combination with temozolomide chemotherapy in glioma patients can produce a certain sensitization effect.However,larger sample size prospective randomized controlled studies are still needed to confirm this.
Glioma of the brainTemozolomide chemotherapyGlutathione peroxidase 4ferroptosis Chemotherapy sensitivity
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