Clinical Characteristics and Related Factors Analysis of Cervical Lymph Node Metastasis in Classic and Follicular Variant of Papillary Thyroid Carcinoma
Objective To explore the clinical characteristics and influencing factors of cervical lymph node metastasis(CLNM)in follicular variant papillary thyroid carcinoma(FVPTC)and classical papillary thyroid carcinoma(CPTC).Methods Retrospective analysis of clinical data of 116 FVPTC patients(FVPTC group)and 110 CPTC patients(CPTC group)who underwent surgical treatment and were con-firmed by intraoperative and postoperative pathological examination at the First Affiliated Hospital of Zhengzhou University from January 2013 to October 2022.Apply a binary Logistic regression model to analyze the independent influencing factors of CLNM in FVPTC and CPTC patients.Results The tumor diameter,ultrasound grading,BRAF gene mutation rate,number of lymph node metastases,thyroid peroxidase antibody(TPOAb),and thyroid stimulating hormone receptor antibody(TRAB)in the FVPTC group were all lower than those in the CPTC group,and the differences were statistically significant(P＜0.05).Tumor size and ultrasound grade are independent risk factors for CLNM in the FVPTC group,while age is an independent protective factor for CLNM.Ultrasound grading is an independent risk factor for CLNM in the CPTC group,and age is an independent protective factor for CLNM.Conclusion There are multiple clinical features of FVPTC that differ from CPTC,which can assist in differential diagnosis.Young patients with large tumor volume and high ultrasound grading are more likely to have CLNM,and more aggressive treatment plans should be adopted.
万方数据
维普
