摘要
目的 观察不同剂量右美托咪定(Dex)口腔黏膜喷雾或滴鼻用于小儿脑电图(EEG)检查的镇静效果.方法 151 例患儿根据Dex口腔黏膜喷雾2.5 ug/kg、3 ug/kg,Dex滴鼻2.5 ug/kg、3 ug/kg,随机分为D1 组(38 例)、D2 组(38 例)、D3 组(37 例)和D4 组(38 例).记录患儿给药前(T0),给药后 10 min(T1)、20 min(T2)、30 min(T3)、40 min(T4)警觉镇静量表(OAA/S)评分、MAP、HR、SpO2.观察患儿镇静一次成功率、诱导时间、检查时间、苏醒时间、不良反应和不同时间点4 组患儿的镇静效果和MAP、HR、SpO2.结果 D1 与D3 组、D1 与D2 组起效时间和D3 与D4 组的苏醒时间差异有统计学意义(P＜0.05);T2 时的D1 与D2 组、D3 与D4 组和T4 时的D3 与D4 组的OAA/S评分差异有统计学意义(P＜0.05);T2 时的 D1 与D2 组的MAP差异有统计学意义(P＜0.05);T1 时的D1 与D2 组、T3 时的D1 与D2 组和D3 与D4 组的HR差异有统计学意义(P＜0.05).结论 小儿EEG检查前应用Dex 3ug/kg滴鼻,诱导时间快、成功率高、镇静效果好,是一种安全有效的EEG检查前的镇静方法.
Abstract
Objective To observe the sedative effect of different doses of dexmedetomidine(Dex)oral mucosal spray or nasal drip in children's electroencephalography(EEG).Methods Totally 151 children were randomly divided into D1(n=38),D2(n=38),D3(n=37)and D4 group(n=38)based on Dex 2.5 μg/kg and 3 μg/kg in oral mucosa spray or nasal drop.The scores of alertness and sedation scale(OAA/S),MAP,HR and SpO2 were recorded baseline(T0)and after administration 10 min(T1),20 min(T2),30 min(T3)and 40 min(T4).The one-time success rate,induction time,examination time,wake-up time,adverse reactions at the sedation and the changes of se-dation effect,MAP,HR and SpO2 of the four groups at different time points were observed.Results The induction time in D1 and D3 groups and D1 and D2 groups,and the wake-up time in D3 and D4 groups were significantly different(P＜0.05);There were statistical differences in the OAA/S scores between D1 and D2 groups and D3 and D4 groups at T2 and between D3 and D4 groups at T4,all P values P＜0.05.There was a statistically significant difference in MAP between D1 and D2 groups at T2(P＜0.05);There were statistical differences in HR be-tween D1 and D2 groups T1 and between D1 and D2 groups and D3 and D4 groups at T3(P＜0.05).Conclusion The Dex 3 μg/kg intranasal instillation before EEG examination in children has fast induction time,high success rate and good sedative effect.It is a safe and effective se-dation method before EEG examination.
基金项目
河南省科技攻关省部共建项目(SBGJ202102210)
河南省科技攻关联合共建项目(2018020689)
NETL
NSTL
万方数据