Differential expression of androgen receptor in breast cancer patients and its correlation with clinicopathological features and immunohistochemistry
Objective To analyze the differential expression of androgen receptor(AR)in breast cancer patients and its correlation with clinicopathological features and immunohistochemistry.Methods A total of 232 breast cancer patients admitted to the First Affiliated Hospital of Zhengzhou University from 2018 to 2019 were selected as the study objects,and divided into groups according to the differences in AR expression levels,in which AR expression levels less than 10％were considered as low expression group,10％～50％as medium expression group,and more than 50％as high expression group.The relationship between different expression levels of AR and clinicopathological features of breast cancer patients was statistically analyzed,and the correlation between different expression levels of AR and other immunohistochemical indicators of breast cancer(ER,PR,Her-2,ki-67 and P53)was also analyzed.Results Among 232 breast cancer patients,69 cases(29.7％)had low AR expression,55 cases(23.7％)had medium AR expression,and 108 cases(46.6％)had high AR expression.Compared with patients with low and medium expression of AR,patients with high expression of AR had lower histological grade,higher positive rate of ER,higher ex-pression of PR,and lower expression of Ki-67(P＜0.05).There was no correlation between AR expression and age,menstrual status,tumor diameter,lymph node metastasis,pathological type and vascular cancer thrombus(P＞0.05).Conclusion High AR positive expression in breast cancer patients is associated with low histological grade,high ER positive rate,high PR expression,low Ki-67 proliferation index and good prog-nostic clinicopathological indicators,suggesting that AR may be a therapeutic target and prognostic indicator for breast cancer.
Breast cancerAndrogen receptorPathological featuresImmunohistochemical index
万方数据
维普
