Effect of laparoscopic surgery with preserved renal units and posterior laparoscopic radical nephrectomy on im-mune function in patients with non-advanced renal cancer
Objective To compare the effect of laparoscopic renal unit-sparing surgery(LNSS)with posterior laparoscopic radical nephrectomy(RLRN)in the treatment of patients with non-advanced renal cancer and the effect on immune function.Methods The data of 150 patients with non-advanced renal carcinoma(from April 2020 to April 2023)in Shangqiu the Third People's Hospital were retrospectively collected and divided into 2 groups according to different surgical protocols.75 patients treated with LNSS were classified as group A and 75 pa-tients treated with RLRN were classified as group B.Preoperative and postoperative renal function[blood urea nitrogen(BUN),creatinine(Scr),gelatinase-associated lipid carrier protein(NGAL)]and the European Cancer Research and Treatment Tissue Quality of Life Scale(EORTC)were compared between the two groups QOL-C30)score,Immune function(CD3+,CD4+,CD4+/CD8+)levels,complication rates.Results The intraoperative blood loss in group A was less than that in group B,BUN,Scr,and NGAL levels at 3d were lower than that of group B,CD3+,CD4+,CD4+/CD8+levels were higher than group B,and the postoperative fasting time and hospitalization time were shorter than those in group B,and the differences were statistically significant(P＜0.05).The EORTC QOL-C30 score was higher than that of Group B and the complication rate was lower than that of Group B(P＜0.05).Conclusion Compared with RLRN in the treatment of non-advanced renal cancer patients,LNSS treatment is more helpful to reduce intraoperative blood loss,reduce the risk of complications,shorten the rehabili-tation process of patients,improve the quality of life,and have less impact on the body's renal function and immune function.
Laparoscopic nephron sparing surgeryRenal cancerRetroperitoneal laparoscopic radical nephrectomyImmune function
万方数据
维普
