Analysis on survival status of AIDS patients over 15 years old receiving antiretroviral therapy and its influencing factors,Xinxiang city,Henan province from 2004 to 2022
Objective To understand the survival status and influencing factors of AIDS patients over 15 years old receiving antiretroviral therapy(ART)in Xinxiang city,Henan province.Methods HIV/AIDS patients over 15 years old were selected from the Free ART Database,Chinese Disease Control and Prevention Information System,and a retrospective cohort study was used to analyze the survival status of patients.Cox proportional risk model was used to explore the related influencing factors of death risk among those receiving ART.Results In total,2 274 patients were included in the study,and the median survival time was 18.0 years.The cumulative survival rate of those receiving ART was 93％.Multivariate Cox proportional risk model analysis showed that the 30-＜50 years old group(AHR=2.316,95％CI:1.283-4.180)and ≥50 years old group(AHR=4.227,95％CI:2.296-7.782),stage Ⅲ based on WHO clinical staging method(AHR=1.771,95％CI:1.306-2.401)and stage Ⅳ(AHR=1.837,95％CI:1.285-2.626),and the initial treatments with zidovudine+desoxyinosine+nevirapine(AHR=1.901,95％CI:1.169-3.092),nevirapine+lamivudine+stavudine and others(AHR=2.368,95％CI:1.404-3.992)had a higher risk of death.The patients being married or having a permanent heterosexual partner(AHR=0.592,95％CI:0.362-0.969),education level with college degree or above(AHR=0.746,95％CI:0.510-1.092),sample from key population(AHR=0.618,95％CI:0.479-0.796),baseline CD4 cell count 200-＜350/μL(AHR=0.712,95％CI:0.593-0.939),350-＜500/μL(AHR=0.577,95％CI:0.376-0.887),≥500/μL(AHR=0.245,95％CI:0.118-0.510)had a lower risk of death.Conclusions The survival rate of patients after ART in Xinxiang city is relatively low.The patients aged 50 and above,being unmarried,with samples from medical institutions,with stage Ⅲ and stageⅣ based on WHO clinical staging method,with junior high school education or below,and those with baseline CD4 cell counts＜200/μL should be targeted for strengthening health education and follow-up care,and improving their medication compliance so as to extend the survival time and improve the quality of life of patients.
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