Molecular typing and source tracing of quinolone resistant Salmonella from different sources in Henan province in 2022
Objective To study the distribution and transmission route of quinolone-resistant Salmonella in diarrhea patients,food and their related environments in Henan province in 2022,and understand the molecular epidemiological characteristics of quinolone-resistant Salmonella in Henan.Methods The antibiotic sensitivity was determined by micro broth dilution method.The multi-locus sequence typing was performed on 107 strains of quinolone-resistant Salmonella isolated from diarrhea patients and 303 strains from food and environment,and then minimum spanning tree was created.Results A total of 27 STs were detected among 221 ciprofloxacin-resistant Salmonella strains,and ST45(59 strains)and ST198(56 strains),accounted for 52.04％(115/221),which were dominant ST types.Among 325 nalidixic acid-resistant Salmonella strains,34 STs were detected with ST1 1(152 strains)and T198(56 strains)being the dominant ST types,accounting for 64.00％(208/325)of the total number of naphthalene acid resistant Salmonella strains.Seven ST forms of ciprofloxacin-resistant Salmonella and 8 ST forms of nalidixic acid-resistant Salmonella were found in diarrhea patients,food and environment.Conclusions In Henan province,there is cross contamination of quinolone-resistant Salmonella between diarrhea patients,food and environment,posing the risk of spread from food and environment to human beings.
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