2020年洛阳市偃师区健康人群A群和C群脑膜炎奈瑟菌抗体水平调查
Antibody levels against group A and C Neisseria meningitis among healthy population in Yanshi district,Luoyang city in 2020
张露露 1仝志琴 1杨闪1
作者信息
- 1. 洛阳市疾病预防控制中心,河南洛阳 471000
- 折叠
摘要
目的 了解河南省洛阳市偃师区健康人群A群和C群脑膜炎奈瑟菌(Nm)抗体水平,为流行性脑脊髓膜炎的预防控制提供科学依据.方法 采用分层随机抽样的方法,于2020年在偃师区选取0～79岁健康人群进行问卷调查和血清标本采集.采用酶联免疫吸附试验检测血清中A群和C群NmIgG抗体,分析其抗体阳性率和中位数浓度(MC).结果 全部628名调查对象的A群、C群Nm抗体总阳性率分别为51.59％、40.76％(x2=14.81,P＜0.05),MC分别为2.13、1.49 μg/mL(H=33.28,P＜0.05).不同年龄组 A 群 Nm抗体阳性率为 13.85％～71.43％(x2=109.40,P＜0.05),1～＜3 岁组最低,20～＜40岁组最高;C群Nm抗体阳性率为13.85％～70.48％(x2=90.98,P＜0.05),0～＜1岁组最低,40～＜60岁组最高.其中＜15岁有明确免疫史人群中,A群Nm抗体阳性率,随着接种剂次从1剂次到4剂次,逐渐升高;C群Nm抗体阳性率,随着接种剂次从0剂次到2剂次,逐渐增高;末次免疫后1～＜2年,A群和C群的Nm抗体水平均降到最低(P均＜0.05).结论 洛阳市偃师区健康人群A群和C群Nm抗体处于较低水平,建议加强流行性脑脊髓膜炎的监测,优化流脑疫苗免疫策略.
Abstract
Objective To explore antibody levels against group A and C Neisseria meningitis(Nm)among a healthy population in Yanshi district,Luoyang city,and provide scientific evidence for the prevention and control of meningococcal meningitis.Meth-ods Serum samples were collected from healthy individuals selected by a stratified random sampling technique in Yanshi district,Luoyang city in 2020.At the same time,a questionnaire-based survey was conducted among the selected individuals.The serum samples were tested by an enzyme-linked immunosorbent assay to detect serum IgG antibodies against group A and C Nm to de-termine positivity rates and median concentrations(MC).Results Among the 628 individuals surveyed,the overall positive rates of antibodies against serogroup A and C Nm were 51.59％and 40.76％,respectively(x2=14.81,P＜0.05),and the MC of the anti-bodies were 2.13 μg/mL and 1.49 μg/mL(H=33.28,P＜0.05),respectively.By age group,positive rates of antibodies against group A ranged from 13.85％to 71.43％(x2=109.40,P＜0.05)with the lowest in the 1-＜3 years old group and the highest in the 20-＜40 years old group,and they ranged from 13.85％to 70.48％against group C(x2=90.98,P＜0.05)with the lowest in the 0-＜1 years old group and the highest in the 40-＜60 years old group.Among the surveyed individuals aged＜15 years and hav-ing the clear vaccination history,the positive rates of antibodies against group A gradually increased with the doses of vaccinations from 1 to 4;they increased from 0 to 2 doses against serogroup C.The antibody levels against group A and C Nm both reached to a minimum 1-＜2 years after last vaccination(all P＜0.05).Conclusions Antibody levels against group A and C Nm among the healthy population in Yanshi district,Luoyang city,were relatively low.It is suggested to strengthen surveillance of meningococcal meningitis and optimize the immunization strategy of meningococcal vaccine.
关键词
流行性脑脊髓膜炎/脑膜炎奈瑟菌/健康人群/抗体水平Key words
Meningococcal meningitis/Neisseria meningitides/Healthy population/Antibody level引用本文复制引用
出版年
2024
NETL
NSTL
万方数据