Efficacy of nerve block therapy for postherpetic neuralgia and its effect on serum interleukin-6 levels
Objective To observe efficacy of nerve block therapy in the treatment of postherpetic neuralgia and its effect on the lev-els of serum interleukin-6(IL-6).Methods A total of 60 patients with postherpetic neuralgia treated in the pain clinic of the Sec-ond Xiangya Hospital,Central South University from Oct 2021 to May 2023 were included.They were randomly divided into an observation group and a control group according to different treatment methods with 30 cases in each group.The control group was conventionally treated with pregabalin and mecobalamin.The observation group was treated with pregabalin,mecobalamin and nerve block under ultrasound guidance.The visual analogue scale(VAS)scores and the levels of serum IL-6 before treatment,one day,one week,one month and three months after treatment were observed and recorded;the therapy efficacy and serum IL-6 lev-els were compared between the two groups.Results Before treatment,the VAS scores in the control group and observation group were(7.00±0.74)and(6.73±0.69)(t=1.439,P＞0.05),respectively,and the serum IL-6 levels in control group and observation group were(93.53±9.15)and(92.10±10.26)ng/L(t=0.570,P＞0.05),respectively.One day after the treatment,the VAS scores in the observation group and control group were(3.97±0.85)and(5.23±0.86)(t=5.742,P＜0.05),respectively,and the IL-6 levels in the observation group and control group were(72.74±7.64)and(83.31±8.54)ng/L(t=5.056,P＜0.05),respectively.One week af-ter the treatment,the VAS score was(3.23±0.77)in the observation group and(4.27±0.69)in the control group(t=5.454,P＜0.05),and the serum IL-6 level was(64.06±6.02)ng/L in the observation group and(75.30±7.89)ng/L in the control group(t=6.204,P＜0.05).One month after the treatment,the VAS score was(2.80±0.93)in the observation group and(3.57±0.57)in the control group(t=3.869,P＜0.05),and the serum IL-6 level was(55.86±3.99)ng/L in the observation group and(64.05±5.74)ng/L in the control group(t=6.420,P＜0.05).Three months after the treatment,the VAS score was(1.87±0.51)in the observation groups and(3.07±0.45)in the control group(t=9.693,P＜0.05),and the serum IL-6 level was(48.10±6.10)ng/L in the observa-tion group and(55.48±3.39)ng/L in the control group(t=5.787,P＜0.05).Conclusions The nerve block can effectively relieve postherpetic neuralgia.
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