2021年河南省1～5岁儿童乙型病毒性肝炎血清标志物监测结果
Results of hepatitis B serum marker surveillance among children aged 1-5 years in Henan in 2021
豆巧华 1张璐 1杨凯朝 1吕宛玉 1杨建辉 1郭永豪 1刘倩 1丰达星 1赵升 1徐瑾 1张延炀1
作者信息
- 1. 河南省疾病预防控制中心,河南郑州 450016;河南省免疫预防医学重点实验室
- 折叠
摘要
目的 了解和分析2021年河南省不同地区1～5岁儿童乙型病毒性肝炎(乙肝)血清标志物的流行状况,评价河南省儿童免疫规划实施的效果.方法 2021年采用横断面调查方法,在河南省18个省辖市的27个县(市、区)随机抽取1 776名1～5岁儿童作为调查对象,开展乙型肝炎免疫状况评估,采用酶联免疫吸附试验检测血清中乙肝表面抗原(HBsAg)、乙肝表面抗体(HBsAb)、乙肝核心抗体(HBcAb).结果 2021年河南省共调查1～5岁儿童1 776名,HBsAg、HBsAb、HBcAb标化阳性率分别为0.15％、74.26％、12.48％.1～5岁各年龄段HBsAb阳性率均＞78.00％,随着年龄的增长HBsAb阳性率逐渐降低(x2趋势=67.833,P＜0.05),1～＜3岁儿童HBsAb阳性率＞90.00％.不同年龄、不同地区、不同接种剂次儿童HBsAb和HBcAb阳性率均存在统计学差异(P均＜0.05).河南省1～5岁乙肝病毒(HBV)易感人群占比为13.18％(234/1 776).结论 河南省1～5岁儿童HBsAg流行率维持在较低水平,年龄、地区、接种剂次对HBsAb、HBcAb阳性率有显著影响,建议各地市密切监测HBsAg流行率.
Abstract
Objective To understand the prevalence of serum hepatitis B virus(HBV)biomarkers among children aged 1-5 in different regions of our province,and evaluate the implementation effect of Henan provincial Immunization Plan for Children.Methods In 2021,a cross-sectional survey was conducted selecting 1 776 children aged 1-5 years as study subjects randomly in 27 counties/cities/districts of 18 cities under the jurisdiction of Henan province.The immunization status of hepatitis B was evaluated.Serum hepatitis B surface antigen(HBsAg),hepatitis B surface antibody(HBsAb)and hepatitis B core antibody(HBcAb)were detected with ELISA method.Results The standardized positive rates of HBsAg,HBsAb,and HBcAb among children aged 1-5 years in Henan province were 0.15％,74.26％,and 12.48％,respectively.The positive rates of HBsAb in every group aged 1-5 years were all more than 78.00％,and the positive rate of HBsAb gradually decreased with the increase of age(x2trend=67.833,P＜0.05);the positive rate among children aged 1-＜3 years and younger was more than 90.00％.There were statistically significant differences in the positive rates of HBsAb among children with different age groups,different regions and different hepatitis B vaccination histories(all P＜0.05).The proportion of HBV susceptible population among children aged 1-5 in Henan province was 13.18％(234/1 776).Conclusions The prevalence of HBsAg in children aged 1-5 years in Henan province remains at a low level,and age,region,and hepatitis B vaccination history have a significant impact on the positivity rates of HBsAb and HBcAb.It is recommended to closely monitor the prevalence of HBsAg in all regions.
关键词
河南省/1～5岁/乙肝Key words
Henan province/Age of 1-5 years/Hepatitis B引用本文复制引用
基金项目
河南省自然科学基金项目(222300420466)
河南省医学科技攻关省部共建项目(2018010028)
河南省医学科技攻关计划联合共建项目(LHGJ20210150)
出版年
2024
NETL
NSTL
万方数据