Monitoring results of adverse events following immunization of human papillomavirus vaccine in Zhengzhou city from 2019 to 2022
Objective To analyze the occurrences of adverse event following immunization(AEFI)for inoculation of human papillomavirus(HPV)vaccine in Zhengzhou city from 2019 to 2022.Methods The AEFI case data from 2019 to 2022 in Zhengzhou city were collected through China Disease Prevention and Control Information System.The HPV vaccine dose data were collected through Henan Provincial Immunization Program Information Management System and Zhengzhou Smart Public Health System.The descriptive epidemiological study was used to analyze.Results The average annual reported incidence of AEFI after HPV vaccination from 2019 to 2022 in Zhengzhou city was 4.57/105 doses,The reported incidences of AEFI caused by HPV2,HPV4 and HPV9 vaccination were 3.42/105 doses,3.55/105 doses and 6.38/105 doses,respectively.The difference was statistically significant(P＜0.05).The incidence was 4.17/105 doses for general reaction,0.30/105 doses for abnormal reactions and 0.10/105 doses for coincidence reaction.The higher reported incidence rates in Xinmi city,Xingyang city and Jinshui district were 11.78/105 doses,8.96/105 doses and 8.94/105 doses,respectively.The incidence was relatively high in the 9-16 age group,which was 11.37/105 doses.AEFI cases were reported every month.The highest incidence was reported from April to June,which was 6.99/105 doses.There were statistically significant differences in reported incidence among different age groups and different months(all P＜0.05).All AEFI cases occurred between 0-24 hours,and 65.22％of them occurred less than 12 hours after inoculation.The abnormal reactions resulted from the second dose of HPV vaccine accounted for 50.00％,and 66.67％abnormal reactions occurred after 12-24 hours.Conclusions The HPV vaccine had a low reported incidence of AEFI in Zhengzhou from 2019-2022,and the main AEFI was general reaction.The HPV vaccination is safe.
Human papillorna virusVaccinationAdverse events following immunizationSurveillance
NETL
NSTL
万方数据
