Analysis of respiratory pathogen detection results and influencing factors in 368 hospitalized patients with severe pneumonia
Objective To understand the general status and influencing factors of respiratory pathogen detection in hospitalized patients with severe pneumonia,and provide the guidance and evidence for clinical treatment.Methods The case data of 368 hospitalized patients with severe pneumonia and the detection results of 19 respiratory pathogens were collected for the analysis.Chi-square test or Fisher's exact test was used for comparison between groups.Multifactor analysis used logistic regression analysis.Results In total,124 patients with positive pathogen infection were detected,with the positive rate of 33.70％,of which 16 were mixed pathogen infections.There were statistically significant differences in SARS-CoV-2(x2=24.679,P＜0.05),Mycoplasma pneumoniae(MP),Rhinovirus(HRV),Human metapneumovirus(HMPV)among different age groups(Fisher's precision probability test,all P＜0.05).The highest detection rate of Influenza A virus(IFA)was 7.88％in the age group of≤14 years.The highest detection rate of SARS-CoV-2 was 18.52％in the age group of ≥61 years.The highest detection rate of MP was 9.02％in the age group of＞14-＜61 years.Of the 16 patients with mixed pathogens infection,there were 12 cases of infants and young children,accounting for 75.00％;11 cases were male patients,accounting for 69.75％;9 cases were infected with HRV,accounting for 56.25％.The multivariate logistic regression analysis results showed that age(OR=1.025,95％CI:1.007-1.042),sampling year(OR=0.456,95％CI:0.265-0.786)and sampling type(OR=5.059,95％CI:2.806-9.122)were independent factors affecting the detection results of respiratory pathogens in hospitalized patients with severe pneumonia.Conclusions Attention should be paid to IFA infection in children and SARS-CoV-2 infection in the elderly,and HRV detection should be actively carried out in children with respiratory tract infections.The lower respiratory tract specimens of patients are preferred for detection for improving the detection rate of pathogens in patients.
Severe pneumoniaRT-PCRMultiple pathogensInfluencing factors
NETL
NSTL
万方数据
