Effect of low concentration of dimethoate exposure on cholinesterase activity in whole blood of workers
Objective To investigate the effects of the organophosphorus pesticide omethoate on cholinesterase activity in whole blood of production workers,and explore the change pattern of cholinesterase activity in whole blood of workers exposed to organophosphorus pesticides.Methods The whole blood cholinesterase activity of 324 workers in an organophosphorus pesticide production factory in 2022 in Kaifeng city was analyzed.They were divided into exposure group and control group according to whether they were exposed to omethoate.The exposure group was categorized according to seniority and exposure degree of workers,and the differences of whole blood cholinesterase activity among all groups were analyzed.Results The concentration of omethoate exposed to each type of work in the enterprise did not exceed the occupational exposure limit.The whole blood cholinesterase activity(9 274.36±2 660.06)KU/L in exposure group was lower than that in control group(9 760.56±1 622.78)KU/L,and the differences was statistically significant(P＜0.05).The whole blood cholinesterase activity of females(8 283.78±2 322.17)KU/L was significantly lower than that of males(9 618.39±2 689.74)KU/L in exposure group(P＜0.05).The whole blood cholinesterase activity in direct exposure group(9 020.91±2 801.31)KU/L was significantly lower than that in indirect exposure group(9 898.22±2 171.22)KU/L(P＜0.05).The exposure group was divided into three categories,less than 3 years,3-20 years and more than 20 years according to the seniority,and the whole blood cholinesterase activity of the workers in the three categories were(9 775.41±2 437.55),(8 325.10±2 536.24),and(9 554.42±2 808.64)KU/L,respectively.The activity of cholinesterase in whole blood of workers with 3 to 20 years of working age was the lowest,and the difference was statistically significant compared to the other two groups(P＜0.05).Conclusions Long-term and low-dose exposure to organophosphorus pesticide omethoate can reduce the activity of cholinesterase in whole blood,and the inhibitory effect of organophosphorus pesticides omethoate on cholinesterase in whole blood increases with the increase of exposure time and degree.
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