Etiological agents and antimicrobial resistance patterns in lower respiratory tract infections among impatients of a tertiary hospital in Xinjiang
Objective To assess the etiological agents and the trends in antibiotic resistance in lower respiratory tract infections among hospitalized patients,and to provide evidence to guide the rational clinical use of antibiotics.Methods A retrospective analysis was conducted on pathogenic strains isolated from sputum samples and their drug susceptibility to common antibiotics from hospitalized patients in our hospital from 2019 to 2022.Results Over the study period,10 080 strains of bacteria were isolated in sputum samples of hospitalized lower respiratory tract infection inpatients.The most prevalent pathogens were 2 579 Klebsiella pneumoniae(25.59％),2 250 Acinetobacter baumannii(22.32％),and 1 828 Pseudomonas aeruginosa(18.13％).Resistance to commonly used antibiotics,including imipenem,meropenem,amikacin,and tobramycin,showed an increasing trend(all P＜0.05),while resistance to piperacillin,ampicillin/sulbactam,piperacillin/tazobactam,cefoperazone/seulbactam,cefuroxime,ceftriaxone,amtrexone,and tigecycline demonstrated a decreasing trend(all P＜0.05).No instances of Staphylococcus aureus resistantance to vancomycin or linezolid was observed.Conclusions The resistance to commonly used antibiotics in the hospital is significant,necessitating enhanced monitoring and management of antibiotic use to prevent further exacerbation of antibiotic resistance.
NETL
NSTL
万方数据
