Risk factors of peripheral neuropathy in patients with chronic mercury poisoning
Objective To analyze the risk factors associated with peripheral neuropathy in patients with chronic mercury poisoning and to facilitate early detection to reduce the risk of complications and disability.Methods The data retrospectively collected for 102 patients treated for chronic mercury poisoning at The Third People's Hospital of Henan Province from 2010 to 2022.Patients were categorized into an injured group(66 cases)and an uninjured group(36 cases)based on neuromyography results.Gender,age,peripheral nerve symptoms,mercury exposure duration,smoking status,hypertension,and nerve conduction velocity were compared between groups.Multivariate logistic regression was used to identify risk factors and construct a predictive nomogram,which was evaluated using a ROC curve and calibration curve.Results The mean age of the injured group(45.24±13.96)years was significantly higher than the uninjured group(35.33±8.59)years(t=3.873,P＜0.05).The mercury exposure duration was longer in the injured group(14.64±5.86)months compared to the uninjured group(8.50±2.90)months(t=5.896,P＜0.05).The injured group showed a higher prevalence of numbness,fatigue,pain,limb fibrillation,and decreased motor and sensory conduction velocities(2.4％vs 11.1％,57.6％vs 27.7％,66.7％vs 22.2％,72.7％vs 9.0％,65.5％vs 22.2％,51.5％vs 11.1％,all P＜0.05).Multivariate logistic regression identified gender(OR=1.740,95％CI:1.107-2.737),age(OR=1.970,95％CI:1.344-2.887),mercury exposure time(OR=4.836,95％CI:2.416-9.678),smoking(OR=3.504,95％CI:1.535-7.998),and hypertension(OR=3.463,95％CI:1.730-6.930)as risk factors.The nomogram demonstrated good calibration(x2H-L=5.378,P＞0.05)and discrimination(AUC=0.909,95％CI:0.795-0.971).Conclusions Gender,age,mercury exposure duration,smoking,and hypertension are significant risk factors for peripheral neuropathy in patients with chronic mercury poisoning.The nomogram model can be utilized for the early detection of peripheral neuropathy and to mitigate the risk of complications and disability.
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