Outcomes of anti-tuberculosis treatment and its influencing factors for TB/HIV co-infected patients in Henan,2016-2021
Objective To analyze the outcomes of anti-tuberculosis treatment for TB/HIV co-infected patients,identify risk factors that might affect the success of this treatment,and inform strategies for the prevention and control of TB/HIV co-infection.Methods TB/HIV co-infected patients registered in TB designated hospitals and received anti-tuberculosis treatment in Henan Province from 2016 to 2021 were included in the study.The outcomes of anti-tuberculosis treatment were analyzed using logistic regression to determine factors that influence the success of the treatment.Results Of the 1 232 patients,the male to female ratio was 3.43:1,with an average age of(47.11±13.85)years;mostly farmers(1 045,84.82％).A total of 1 167 cases were successfully treated(94.72％).Of which 439 cases were cured,representing a cure rate of 35.63％.A total of 728 patients completed the course of treatment,with a completion rate of 59.09％,a total of 56 cases were not successfully treated resulting in an unsuccessful treatment rate of 4.55％.The main reason for unsuccessful treatment was deaths from non-tuberculosis diseases,accounting for 1.87％of the cases.Multivariate logistic regression analysis identified that a known positive HIV test(OR=2.053,95％CI:1.157-3.643)was a significant risk factor for unsuccessful anti-tuberculosis treatment in TB/HIV co-infected patients.Conclusions The study concludes that TB/HIV co-infected patients with a known positive HIV tests are at higher risk of unsuccessful anti-TB treatment,which may lead to adverse consequences.It suggests that there is a need to enhance health education and monitor the effectiveness of TB treatment in this population to improve the rate of successful treatment.
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