摘要
目的 分析结核/艾滋病(TB/HIV)双重感染患者的抗结核治疗效果,找出可能影响抗结核治疗成功的危险因素,为TB/HIV合并感染的预防和控制策略提供依据.方法 选取2016-2021年在河南省结核病定点医疗机构登记并接受抗结核治疗的TB/HIV双重感染患者均纳入研究,采用logistic回归分析抗结核治疗转归情况,以确定影响治疗成功的因素.结果 1 232例患者中,男女比例3.43:1,平均年龄(47.11±13.85)岁,多为农民(1 045例,84.82％).成功抗结核治疗1 167例(94.72％),其中,治愈439例,治愈率35.63％;完成疗程728例,完成治疗率59.09％.未成功治疗56例,未成功治疗率4.55％,未成功治疗的原因主要是非结核死亡,占1.87％.多因素logistic回归分析显示,已知HIV检查阳性(OR=2.053,95％CI:1.157～3.643)是TB/HIV双重合并感染患者抗结核治疗不成功的显著危险因素.结论 已知HIV检查阳性TB/HIV合并感染患者抗结核治疗未成功的风险更高,这可能导致不良后果.表明有必要加强健康教育,监测此类人群的结核治疗效果,以提高治疗成功率.
Abstract
Objective To analyze the outcomes of anti-tuberculosis treatment for TB/HIV co-infected patients,identify risk factors that might affect the success of this treatment,and inform strategies for the prevention and control of TB/HIV co-infection.Methods TB/HIV co-infected patients registered in TB designated hospitals and received anti-tuberculosis treatment in Henan Province from 2016 to 2021 were included in the study.The outcomes of anti-tuberculosis treatment were analyzed using logistic regression to determine factors that influence the success of the treatment.Results Of the 1 232 patients,the male to female ratio was 3.43:1,with an average age of(47.11±13.85)years;mostly farmers(1 045,84.82％).A total of 1 167 cases were successfully treated(94.72％).Of which 439 cases were cured,representing a cure rate of 35.63％.A total of 728 patients completed the course of treatment,with a completion rate of 59.09％,a total of 56 cases were not successfully treated resulting in an unsuccessful treatment rate of 4.55％.The main reason for unsuccessful treatment was deaths from non-tuberculosis diseases,accounting for 1.87％of the cases.Multivariate logistic regression analysis identified that a known positive HIV test(OR=2.053,95％CI:1.157-3.643)was a significant risk factor for unsuccessful anti-tuberculosis treatment in TB/HIV co-infected patients.Conclusions The study concludes that TB/HIV co-infected patients with a known positive HIV tests are at higher risk of unsuccessful anti-TB treatment,which may lead to adverse consequences.It suggests that there is a need to enhance health education and monitor the effectiveness of TB treatment in this population to improve the rate of successful treatment.
基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20210153)
NETL
NSTL
万方数据