Survey of Neisseria meningitidis antibody levels among the healthy population in Tangyin County,Anyang City,2017-2022
Objective To analyze the level of Neisseria meningitidis(Nm)IgG antibody among the healthy population in Tangyin County,Anyang City,so as to provide evidence for improving immunization strategy against epidemic cerebrospinal meningitis.Methods Using multistage stratified sampling method,questionnaire survey was conducted among the healthy people in Tangyin County during winter and spring from 2017 to 2022,and the serum samples were collected and tested using enzyme-linked immunosorbent assay(ELISA)for detecting IgG antibodies of group A and group C Nm,and IgG antibody protection rate and Median concentration(MC)of them were analyzed.Results Among the 1 089 subjects,the overall protective rates of group A and group C Nm IgG(≥2 μg/mL)were 59.65％and 48.91％(x2=25.550,P＜0.05),and MC were 2.68 μg/mL and 1.94 μg/mL,respectively.By age group,the protective rate of group A Nm IgG ranged from 27.15％to 84.62％(x2=175.893,P＜0.05),with the highest protective rate in the group aged greater than or equal to 20 years;the protective rate of group C Nm IgG ranged from 28.86％to 59.33％(x2=47.561,P＜0.05),with the highest protective rate in the group aged 3-＜5 years.The protective rates of Nm IgG antibody in different occupations ranged from 37.16％to 84.85％in Group A Nm IgG(x2=108.615,P＜0.05)and from 38.18％to 65.15％in Group C Nm IgG(x2=32.219,P＜0.05).The protective rates of group A Nm IgG for the groups having immunization and having no or unknown immunization history were 55.31％and 78.82％(x2=38.001,P＜0.05),respectively.The protective rates of group C Nm IgG for the groups having immunization and having no or unknown immunization history were 48.09％and 51.54％(x2=0.944,P＞0.05),respectively.Among the population aged from 0-＜15 years,with the increase of the immunization doses,the protective rate increased from 18.75％to 70.00％for group A Nm IgG and from 19.35％to 76.47％for group C Nm IgG.Conclusions The protection rates of Group A and Group C Nm IgG antibody among the healthy population in Tangyin County,Anyang,were relatively low.It is suggested that the immunization strategy should be adjusted to strengthen and optimize the Neisseria meningitidis vaccination among young children,teenagers and adults in a timely manner to enhance immunity of the population.
Neisseria meningitidisEpidemic cerebrospinal meningitisProtection rate of IgG antibodyHealthy population
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