Mother-to-child transmission blocking and its influencing factors in 178 cases of HBsAg positive pregnant women at a monitoring site in Henan Province in 2021
Objective To conduct post-vaccination serological test(PVST)on newborns born to mothers for hepatitis B virus surface antigen(HBsAg)positive after immunized with hepatitis B vaccine(HepB)and hepatitis B immunoglobulin(HBIG),to evaluate the effectiveness of mother-to-child transmission blocking of the treatment.Non-responsive babies were re-vaccinated with the hepatitis B vaccine,aiming to reduce the risk of neonatal HBV infection.Methods Newborns born to HBsAg-positive mothers in Huaiyang District,a national PVST monitoring site in Zhoukou City,Henan Province in 2021,were selected as study objects.Blood samples were collected for antibody monitoring within 1-2 months after immunized with hepatitis B vaccine and hepatitis B immunoglobulin concurrently.Babies with HBsAg negative and anti-HBS negative were re-immunized with hepatitis B vaccine.Results A total of 178 subjects were included in the study.All newborns were immunized with HepB and HBIG timely.Successful blocking was achieved in 174 cases,resulting in a 97.8％success rate.Among 36 susceptible children identified,18 completed the re-immunization and all protective antibodies,yielding a 100.0％re-immunization success rate.No specimens were collected from18 newborns.Among them,7 completed the immunization and 11 did not.The success rate of mother-to-child blocking was significantly higher in HBsAg group(99.2％)than in the HBsAg+HBeAg group(93.6％)(P＜0.05).No significant differences were observed in success blocking rates across different maternal ages,education levels,courses of hepatitis,or delivery modes(x2=0.07,0.07,2.67,0.35,P＞0.05).Similarly,no significant differences were found among children of different sexes,gestational age,parities and weight(x2=0.69,0.48,0.00,1.10,P＞0.05).Conclusions For newborns born to HBsAg positive mothers,the combination of HepB and HBIG immunization and antibody level monitoring can effectively identify and re-immunize susceptible children,thereby improving the success rate of blocking immunization.
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