Virological effects and influencing factors of antiviral treatment on HIV/AIDS cases in Kaifeng City,Henan Province,2013-2022
Objective To analyze the results and influencing factors of viral load of HIV/AIDS cases in Kaifeng after antiviral treatment.Methods A retrospective study was conducted.Information related to HIV/AIDS cases over 15 years old in Kaifeng from January 1,2013 to December 31,2022 was collected through the Basic Information System for AIDS Prevention and Control.The results and influencing factors of viral load were analyzed.Results Of the 1 264 HIV/AIDS cases included in the analysis,86.4％had viral load of less than 50 copies/mL,7.1％had viral load of 50-1 000 copies/mL,and 6.5％had viral load of≥1 000 copies/mL after antiviral treatment.Virological treatment failure occurred in 112(8.9％)cases.Multivariate logistic regression analysis demonstrated that the OR(95％CI)were 2.057(1.308-3.234)and 3.206(1.499-6.859)for the groups of 41-＜66 years old and ≥ 66 years old(taking the group of 15-＜41 years old as a reference),respectively,and 2.436(1.363-4.355)for the group with time intervals between HIV diagnosis and ART initiation＞12 months(taking the group≤1 month as a reference),suggesting that the groups aged 41-＜66 years old and ≥66 years old aged,and the group with time intervals between HIV diagnosis and ART initiation＞12 had a higher risk of virological treatment failure;taking the group with treatment＜1 year as a reference,the OR(95％CI)for the groups with treatment between 1 to＜3 years,3-＜5 years,and＞5 years were 0.196(0.111-0.346),0.190(0.108-0.335),and 0.127(0.072-0.222),respectively,suggesting that the groups with treatment intervals between 1-＜3 years,3-＜5 years,and more than 5 years had a lower risk of virological treatment failure.Conclusions The antiviral treatment for HIV/AIDS cases in Kaifeng was effective.To ensure that patients get long-term standardized treatment,we should increase publicity,improve the ability of early detection,focus on patients over 40 years old,perform regular follow-up tests and strength communication of doctor-patient.
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