Molecular transmission characteristics of newly reported HIV-1 infected cases in Henan Province in 2023
Objective To elucidate the molecular transmission characteristics of newly reported HIV-1 infected cases in Henan Province,so as to provide a basis for epidemic development and prevention.Methods Blood samples were collected from 8 cities in Henan Province from individuals newly-diagnosed with HIV-1 and untreated by antiretroviral therapy in the second quarter of the 2023,the HIV-1 pol gene was amplified using reverse transcription-polymerase chain reaction(RT-PCR),followed by se-quencing,alignment,and construction of molecular transmission network.Results A total of 209 successful pol sequences were obtained,representing 10 subtypes or circulating recombinant forms(CRF).The predominant subtypes were CRF07_BC(45.45％),CRF01_AE(23.44％),and B(20.57％).Forty-one pol gene sequences were utilized to construct 16 molecular trans-mission networks with a clustering rate of 19.62％,with CRF07_BC showing the highest number of transmission clusters.Logistic regression analysis indicated that individuals over 70 years of age(compared with individuals of 18-＜25 age group,OR=5.45,95％CI:1.16-25.66),those who engaged in housework or unemployed(compared with farmers,OR=2.84,95％CI:1.31-6.13),and residents of Anyang region were more likely to be part of the HIV-1 molecular transmission network compared to their re-spective reference groups.Conclusions The HIV-1 diversity among newly reported cases in Henan Province is significant,with CRF07_BC,CRF01_AE and B subtypes being predominant.Establishment of a molecular transmission network for ongoing surveillance is essential to implement targeted interventions to curb the spread of the virus.
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