Simultaneous determination of five disinfection by-products and perchlorate in finished water by UPLC-MS/MS
Objective To establish an ultra-performance liquid chromatography-tandem mass spectrometry method for the determina-tion of dichloroacetic acid,trichloroacetic acid,bromate,chlorate,chlorite and perchlorate in finished water.Methods The water samples were filtered by 0.22 μm hydrophilic membrane,then were separated on the Acclaim Trinity P1 Column(100 mm×2.1 mm,3.0 μm)and analyzed using gradient elution of acetonitrile-20 mmol/L ammonium formate,electrospray negative ion mode,and multi-reaction monitoring mode.By comparing the matrix effect,six target substances were quantitatively analyzed by the standard curve method prepared by ultra-pure water.Results The six target substances all showed good linear relationships within the linear range(r≥0.995),with a detection limit of 0.068-0.800 μg/L and a quantification limit of 0.14-2.40 μg/L.The spike experiments with low,medium and high concentrations were carried out with tap water as the base,and the average recovery rates were from 88.6％-105.3％,and the ranges of relative standard deviation were from 1.5％-5.6％.Conclusions The proposed method is rapid,simple,sensitive and reproducible,and can be used for the detection of the five disinfection by-products and perchlorate in finished water.
Ultra-performance liquid chromatography-tandem mass spectrometryDisinfection by-productsPerchlorateFinished water
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