Analysis of vaginal microecological characteristics in HR-HPV positive patients with different grades of cervical lesions
Objective To explore the relationship between vaginal microecological environment,high-risk human papillomavirus(HR-HPV)infection,and cervical lesions.Methods A total of 300 patients with cervical diseases and 60 ordinary patients who underwent cervical examination in Zhengzhou Maternal and Child Health Hospital in 2023 were selected for vaginal microbiota and HR-HPV testing,and the status of HR-HPV infection,reduction of lactic acid bacteria,proline aminopeptidase(GADP),leukocyte esterase(LE),vaginal pH and vaginal microbiota in patients with different types of cervical lesions were compared and analyzed.Results The 300 patients with cervical diseases included 102 cases of chronic cervicitis,90 cases of low-grade squamous intraepithelial lesions(LSIL),76 cases of high-grade squamous intraepithelial lesions(HSIL),and 32 cases of cervical squamous cell carcinoma(SCC).The positive rates of HR-HPV in the SCC group,HSIL group,and LSIL group were 81.3％,53.9％,and 33.3％,respectively,which were higher than those in the chronic cervicitis group,which was 13.7％(all P＜0.05).The results of Spearman correlation analysis showed that the decrease of lactobacilli in the vagina,the vaginal pH value greater than 4.5,and the vaginal microbiota density of Ⅲ and IV were significantly correlated with HR-HPV infection(r=0.520,0.501 and 0.487,respectively;all P＜0.05).Conclusions The abnormal changes of microecological environment in the vagina of patients with cervical lesions and HR-HPV infection are closely correlated with cervical lesions.
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