Association of NLR and PLR Level with Prognostic Regression and Survival Duration in Patients with Non-small Cell Lung Cancer
Objective To investigate the association of NLR and PLR before immunotherapy with prognostic regression and survival duration in patients with non-small cell lung cancer.Methods 102 pa-tients with non-small cell lung cancer who received immunotherapy were selected for the study.All pa-tients were followed up for a period of 1 year after the end of immunotherapy and were divided into a sur-vival group(45 patients)and a death group(57 patients)based on the results of the follow-up.We compared the general data and the NLR and PLR indexes of the 2 groups of patients before immunotherapy,grouped the patients using the ROC curve to select the best cutoff value,compared the differences in sur-vival,and analyzed the factors affecting the prognosis of patients with non-small-cell lung cancer using the Cox risk-proportional regression model.Results There were significant differences between the sur-vival group and the death group in terms of age,smoking history,pathological type,pathological stage,NLR,PLR,etc.(P<0.05).Grouping non-small cell lung cancer patients according to the optimal cut-off value,the 1-year cumulative survival rate of patients in the low NLR group was 58.47%,and that of patients in the high NLR group was 31.75%;the 1-year cumulative survival rate of patients in the low NLR group was higher than that of patients in the high NLR group,and the difference was statistically significant(P<0.05).The 1-year cumulative survival rate was 60.82%for patients in the low PLR group and 34.26%for patients in the high PLR group,and the 1-year cumulative survival rate of patients in the low PLR group was higher than that of the high PLR group(P<0.05).Multifactorial Cox regres-sion analysis showed that age≥60 years,pathological stage IV,NLR≥3.57,and PLR≥168.42 were the risk factors affecting the prognosis of patients with non-small cell lung cancer,and the difference was statistically significant(P<0.05).Conclusion The levels of NLR and PLR before immunotherapy are correlated with the prognosis and survival time of patients with non-small cell lung cancer.The higher the levels of NLR and PLR,the poorer the prognosis and the shorter the survival duration.
万方数据
维普
