Objective To explore the clinical effect of ow-dose aspirin combined with labetalol in the treatment of hypertension disorders in pregnancy(HDP).Methods Seventy-six pregnant women with HDP were selected,and 30 pairs of patients were successfully matched according to the 1∶1 propensity matching scoring method,and divided into a control group(30 patients,labetalol treatment)and an observation group(30 patients,low-dose aspirin and labetalol combination).Blood pressure,urine protein status,serum and placental growth factor(PLGF)and pregnancy associated protein A(PAPP-A)levels,coagulation,inflammatory chemokines[chemokine ligand 16(CXCL16),fractalkine(FKN),monocyte chemoattractant protein 1(MCP-1)],mode of delivery,pregnancy outcome and obstetric complications of both two groups were analyzed and compared.Results At 7 d after the administration of the drug,the systolic blood pressure,diastolic blood pressure and 24-hour urinary protein levels of pregnant women in the two groups were lower than those before treatment,and the observation group showed lower indicators compared with the control group with a statistically significant difference(P<0.05).Before delivery,the levels of PAPP-A in serum and placenta of pregnant women in the two groups were lower and the levels of PLGF in serum and placenta were higher than those before drug administration,and the levels of PAPP-A in the observation group were lower than those in the control group and the levels of PLGF were higher than those in the control group,and the difference was statistically significant(P<0.05).Before delivery,the prothrombin time(PT)and activated partial thromboplastin time(APTT)in the two groups were longer and the FIB level was lower than those before drug administration,and the PT and APTT in the observation group were longer than those in the control group,and the fibrinogen(FIB)level was lower than that in the control group,and the difference was statistically significant(P<0.05).Before delivery,the levels of CXCL16,FNK,and MCP-1 of pregnant women in the two groups were lower than those before drug administration,and the levels of CXCL16,FNK,and MCP-1 in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Tracking to the delivery of pregnant women,the cesarean section rate and premature delivery rate of 20.00%and 6.67%in observation group were lower than 46.67%and 26.67%in control group(all P<0.05).There was no statistical difference in the incidence rate of obstetric complications between observation group and control group(10.00%vs 23.33%)(P>0.05).There were no serious adverse reactions in pregnant women in either group during the medication period.Conclusion The application of low-dose aspirin in pregnant women with HDP can effectively reduce the blood pressure,lower the PAPP-A and increase the PLGF,improve the coagulation function of pregnant women,lower the levels of inflammatory chemokines,and help ensure the maternal-infant safety.
hypertensive disorders in pregnancylow-dose aspirinlabetalolplacental growth factorcoagulation function
维普
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