Objective To investigate the expression levels of serum amyloid A protein(SAA),procalcitonin(PCT),Treg cells and related factors in patients with multidrug-resistant organism(MDRO)pneumonia infection and the related correlation with efficacy.Methods Ninety-seven patients with MDRO pneumonia infection were selected for the study and were divided into an effective group(73 patients)and an ineffective group(24 patients)based on the therapeutic efficacy after 14 d of treatment.All patients were categorized into three subgroups based on the pneumonia severity index(PSI)at the time of admission:low-risk(34 patients),intermediate-risk(49 patients)and high-risk(14 patients)group.In this study,the levels of SAA,PCT,Treg cells,ultrasensitive C-reactive protein(hs-CRP)and tumour necrosis factor-α(TNF-α)were compared between the two groups before treatment and after 7 d and 14 d of treatment.At the same time,the serum index levels and PSI scores of low-risk,intermediate-risk and high-risk patients were compared before and after treatment,and the related correlation of above-mentioned indicators was analyzed.Results Compared with the ineffective group,SAA,PCT,hs-CRP and TNF-α levels were lower and Treg cell count was higher in the effective group after 7 and 14 d of treatment(P<0.05).Before treatment,SAA,PCT,hs-CRP,TNF-α levels and PSI scores gradually increased in low-,intermediate-and high-risk patients;while Treg cell counts gradually decreased,with statistically significant differences(P<0.05).Before treatment,the levels of SAA,PCT,hs-CRP,and TNF-α were positively correlated with the PSI score,and the number of Treg cells was negatively correlated with the PSI score(P<0.05).Subject operating characteristic(ROC)curves showed that the AUC of combining SAA,PCT,Treg cells,hs-CRP and TNF-α to predict treatment inefficacy was greater than each individual indicator.Conclusion SAA,PCT,hs-CRP,TNF-α and Treg cell counts can be abnormally expressed in patients with MDRO pneumonia infection,and the expression levels have an important effect on prognosis.Therefore,the clinic can monitor the changes of the levels,and the combined indicators have a high value in predicting prognosis.
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