Objective To explore the molecular mechanism of Zhi Bai Di Huang Tang Chemical Formula against idiopathic central precocious puberty using network pharmacology.Methods The Chinese Medicine System Platform was used to collect the active ingredients of Zhi Bai Di Huang Tang;PubChem and Uniprot databases were used to obtain the target genes of the main active ingredients of Zhi Bai Di Huang Tang;DisGeNET database was used to obtain the targets of idiopathic precocious puberty;and the protein interaction network model and KEGG metabolism pathway analysis were performed by the STRING database and the Cytoscape software.STRING database and Cytoscape software were used to construct protein interaction network model and analyze KEGG metabolic pathway;Finally,PyMOL software was used for drawing.Results In this study,61 active ingredients were obtained,including 13 disease-related intersecting gene targets and 3 important signaling pathways.Conclusion The formula of Zhi Bai Di Huang Tang mainly exerts its therapeutic effects on idiopathic central precocious puberty through multi-components,multi-targets,and multi-pathways,which provides a certain theoretical basis for clinical treatment.
关键词
特发性中枢性性早熟/网络药理学/知柏地黄汤化裁方/信号通路/分子机制
Key words
idiopathic central precocious puberty/Network Pharmacology/Zhi Bai Di Huang Tang Chemical Formula/signaling pathway/molecular mechanism
维普
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