Analysis of Related Factors of Thrombotic Events in Elderly Patients with Paroxysmal Atrial Fibrillation Implanted with Pacemaker
Objective To explore the relationship between changes in left ventricular function and serum levels of interleukin-17A(IL-17A)and albumin(Alb)and the occurrence of thrombotic events in elderly patients with paroxysmal atrial fibrillation implanted with pacemakers.Methods A total of 150 elderly patients with paroxysmal atrial fibrillation who had been implanted with pacemakers and were followed up for a long time in the outpatient department of our hospital were selected as the research objects.Left ventricular function and serum levels of IL-17A and Alb were detected on the day of enrollment.All patients were followed up for 2 years.Finally,according to the presence or absence of thrombotic end events during the follow-up period,they were divided into thrombus group(n=20)and control group(n=130).The general data,left ventricular function,serum levels of IL-17A and Alb were compared between the two groups,and their correlation with thrombotic events was analyzed.Results After 2 years of follow-up,a total of 20 thrombotic events occurred,including 14 cases of stroke and 6 cases of peripheral arterial embolism.The proportions of hypertension and diabetes in the thrombus group were higher than those in the control group,and the proportion of taking anticoagulant drugs was lower than that in the control group,with statistically significant differences(P<0.05).The level of left ventricular ejection fraction(LVEF)in the thrombus group was lower than that in the control group,and the levels of left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)were higher than those in the control group,with statistically significant differences(P<0.05).Serum Alb in the thrombus group was lower than that in the control group,and the level of IL-17A was higher than that in the control group,with statistically significant differences(P<0.05).Multivariate logistic regression analysis showed that hypertension,diabetes,low left ventricular function,high serum IL-17A level and low serum Alb level were all independent risk factors for thrombotic events in elderly patients with paroxysmal atrial fibrillation implanted with pacemakers(P<0.05),and taking anticoagulant drugs was a protective factor for thrombotic events(P<0.05).Spearman correlation analysis showed that LVESD,LVEDD in left ventricular function and serum IL-17A level were positively correlated with thrombotic events in elderly patients with paroxysmal atrial fibrillation implanted with pacemakers(P<0.05),and LVEF and serum Alb level were negatively correlated with thrombotic events(P<0.05).Conclusion Diabetes,hypertension,anticoagulant drugs,left ventricular function and serum levels of IL-17A and Alb are all influencing factors of thrombotic events in elderly patients with paroxysmal atrial fibrillation implanted with pacemakers.
paroxysmal atrial fibrillationimplanted with pacemakerleft ventricular functioninter-leukin-17Aserum albuminthrombotic event
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