Application of IVIM-DWI and DCE-MRI in the Differential Diagnosis of Benign Prostatic Hyperplasia and Prostate Cancer
Objective To observe the significance of intravoxel incoherent motion diffusion-weighted imaging(IVIM-DWI)and dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in the differential diagnosis of benign prostatic hyperplasia and prostate cancer.Methods The clinical data of 115 patients diagnosed as benign prostatic hyperplasia and prostate cancer by pathological analysis were retrospectively analyzed.Patients with benign prostatic hyperplasia were included in the benign group(80 cases),and patients with prostate cancer were included in the malignant group(35 cases).All patients underwent IVIM-DWI and DCE-MRI examinations.The differences in quantitative parameters of IVIM-DWI[apparent diffusion coefficient(ADC),true diffusion coefficient(D),perfusion fraction(f)]and DCE-MRI[transfer constant(Ktrans),rate constant(Kep),extracellular extravascular volume fraction(Ve)]between the two groups were compared.The receiver operating characteristic(ROC)curve was used to analyze the differential diagnostic efficacy of the two methods.Pearson correlation coefficient was used to analyze the correlation between the two methods and Gleason score.Results ADC,D,f,and Ve in the malignant group were lower than those in the benign group,and Ktrans and Kep were higher than those in the benign group(P<0.05).The areas under the curve(AUC)of ADC,D,f,Ktrans,Kep,and Ve for the differential diagnosis of benign prostatic hyperplasia and prostate cancer were 0.951,0.831,0.725,0.708,0.849,and 0.787,respectively.There were significant differences in ADC and D among patients with different Gleason scores in the malignant group(P<0.05),but there were no significant differences in f,Ktrans,Kep,and Ve(P>0.05).ADC and D were negatively correlated with Gleason score(P<0.05),while f,Ve,Ktrans,and Kep were not correlated with Gleason score(P>0.05).Conclusion Both IVIM-DWI and DCE-MRI can effectively distinguish benign prostatic hyperplasia from prostate cancer.Among them,the quantitative parameters ADC and D of IVIM-DWI can be used as a reference for disease assessment.
NETL
NSTL
万方数据
