Application of CT Perfusion Parameters in Evaluating Collateral Status and Hemorrhagic Transformation after Thrombolysis in Patients with Acute Cerebral Infarction
Objective To explore the application value of CT perfusion parameters in evaluating collateral status and hemorrhagic transformation after thrombolysis in patients with acute cerebral infarction.Methods A total of 100 patients with acute cerebral infarction were selected as the research objects and divided into a bleeding group(n=48)and a non-bleeding group(n=52)according to whether hemorrhagic transformation occurred.CT perfusion examinations were performed on all patients,and the CT perfusion imaging parameters of the collateral circulation status of the patients were recorded.The relative cerebral blood volume(rCBV),relative cerebral blood flow(rCBF),relative mean transit time(rMTT),and relative time to peak(rTTP)of CT perfusion parameters were compared between the two groups.The rCBV,rCBF,rMTT,and rTTP of the affected side and the healthy side of the patients in the bleeding group were compared,and multivariate logistic regression analysis was used to analyze the independent prognostic conditions of the above indicators.Results The rCBV and rCBF of patients in the bleeding group were smaller than those in the non-bleeding group,and the difference was statistically significant(P<0.05).The rTTP of patients in the bleeding group was higher than that in the non-bleeding group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in rMTT between the two groups(P>0.05).The rCBV and rCBF on the affected side of patients in the bleeding group were smaller than those on the healthy side,and the rMTT and rTTP on the affected side were higher than those on the healthy side.The difference was statistically significant(P<0.05).Multivariate logistic regression analysis showed that rCBV,rCBF,and rTTP could all be used as predictors of independent hemorrhagic transformation after thrombolysis(P<0.05).The smaller the rCBV and rCBF,the greater the degree of independent hemorrhagic transformation after thrombolysis.The larger the rTTP,the greater the degree of independent hemorrhagic transformation after thrombolysis.However,rMTT could not be used as a predictor of independent hemorrhagic transformation after thrombolysis(P>0.05).Conclusion rCBV,rCBF,and rTTP among different parameters of CT perfusion can be used to evaluate collateral status and hemorrhagic transformation after thrombolysis in patients with acute cerebral infarction,providing certain clinical guiding significance for personalized treatment of patients.
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