Evaluated of Novel and Traditional Inflammatory Markers on Bacterial Infection in Patients with Hematological Diseases
Objective To explore the diagnostic value of novel and traditional inflammatory markers,including human neutrophil apolipoprotein(HNL),neutrophil CD64(nCD64)procalcitonin(PCT)and white blood cell(WBC)count,for bacterial infection of hematological diseases.Methods The clinical data of 85 patients with bacterial infected blood diseases were retrospectively analyzed and set as the infected group,and another 62 patients with non-bacterial infected blood diseases in the same period were selected as the non-infected group.The general data,peripheral blood HNL,nCD64,PCT,WBC count were compared between the two groups.Receiver operating characteristic(ROC)curve was used to describe the diagnostic efficiency of the above indicators on patients with bacterial infections in haematological disorders.Results The levels of peripheral blood PCT,HNL,nCD64,WBC count and combined prediction in infection group were higher than those in non-infected group(P＜0.001).The sensitivities of PCT,HNL,nCD64,WBC count and combined prediction in the diagnosis of hematological diseases with bacterial infection were 81.18％,82.35％,78.82％,77.65％and 96.47％,and the specificities were 85.88％,89.41％,88.68％,88.24％and 78.82％respectively.The results of the ROC curve showed that the area under the curve for PCT,HNL,nCD64,WBC count levels and combined predictive diagnosis of bacterial infections in blood disorders were 0.871,0.907,0.891,0.788 and 0.984,respectively.Conclusion The levels of PCT,HNL,nCD64 and WBC count in peripheral blood have evaluated value in the diagnosis of hematological diseases with bacterial infection,and combined prediction has the greatest diagnostic value.
万方数据
维普
