Study on TCM in the Treatment Mechanism of Polycystic Ovarian Syndrome Based on Intestinal Microecology
The intestinal microecological disorder is an important factor involved in the occurrence and development of polycystic ovarian syndrome(PCOS).Based on intestinal microecology,TCM has achieved multi-level and multi-target treatment of PCOS by promoting the abundance of probiotics,repairing intestinal barrier function,and regulating intestinal metabolites.However,there are still the follow-ing problems in the study of intestinal microecology:(1)The relationship between disease and flora is still limited to the paradigm of correlation research,and there is a lack of causal conclusions based on germ-free mice or fecal microbiota colonization studies.(2)In clinical diagnosis,there is no large-sample multi-center clinical trials to screen out flora markers that can be used as diagnostic markers for PCOS.(3)The pathological mechanism of PCOS mediated by intestinal flora is still considered to be influenced by the overall sys-tem of metabolism,inflammation,and immunity,and there is a lack of specific mechanism studies.(4)The various syndromes of PCOS in TCM are lack of unified standards,which limits the standardized diagnosis and treatment of PCOS based on intestinal flora.(5)TCM treatment is mainly in the form of classic compounds with supplement,which lacks standardized pathological treatment methods,as well as drug metabolism and kinetics research,and the multi-component regulation mechanism of compounds is still unclear.In the future,it is necessary to conduct in-depth research on intestinal flora and metagenomics detection by constructing PCOS animal models and col-lecting PCOS clinical samples.Meanwhile,TCM treatment of PCOS from macroscopic syndrome to microscopic molecular biological mechanism still needs to be carried out,especially the research on the regulation of single bacteria of intestinal flora and the micro-regu-lation of flora genome,metabolome and transcriptome,so as to further clarify the material basis and metabolic characteristics of TCM compounds for treating PCOS based on the intestinal flora mechanism,and provide a reliable theoretical basis for TCM compounds for treating PCOS.
polycystic ovary syndromeintestinal microecologyintestinal floraTCM therapycompound formulas of Chinese medicinals compoundsmonomers of Chinese medicinalsacupuncture therapy
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